Chrysophanol delays aging via insulin/IGF-1 signaling pathway.

Aging is inevitable processes which play a significant role in the development of various diseases, including cardiovascular diseases, neurodegenerative disorders, and cancers. The extension of lifespan and the improvement of age-related diseases can potentially be achieved by targeting evolutionarily conserved pathways and mechanisms through pharmacological interventions. Chrysophanol (Chr), a naturally occurring anthraquinone compound primarily derived from rhubarb of the Polygonaceae family, exhibits a wide range of pharmacological activities, including anti-cancer, anti-inflammatory, and anti-bacterial effects.

Thrombospondin-1 binds to integrin β3 to inhibit vascular calcification through suppression of NF-κB pathway.

Vascular calcification is an important risk factor related to all-cause mortality of cardiovascular events in patients with chronic kidney disease (CKD). Vascular extracellular matrix (ECM) proteins have been demonstrated to regulate vascular calcification. ECM protein thrombospondin 1 (THBS1/TSP-1) plays a critical role in the regulation of vascular diseases.

Escape from TGF-β-induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells.

Transforming growth factor-β (TGF-β) signaling and cellular senescence are key hallmarks of hepatocellular carcinoma (HCC) pathogenesis. Despite provoking senescence-associated growth arrest in epithelial HCC cells, elevated TGF-β activity paradoxically correlates with increased aggressiveness and poor prognosis in advanced tumors. Whether the transition between these dichotomous functions involves modulation of the senescence phenotype during disease progression remains elusive.

miR-34a-5p modulation of polycystic ovary syndrome via targeting the NOTCH signaling pathway.

Purpose: Polycystic ovary syndrome (PCOS) is currently recognized as a condition that affects several systems in the body, including the reproductive, endocrine, and cardiovascular systems. Prevalent among teenagers and women of reproductive age. Prior research has demonstrated an elevation of miR-34a-5p within the follicular fluid (FF) of women of PCOS.

Healthcare utilization in the departments of obstetrics and gynecology during the first two years of the COVID-19 pandemic: time series analysis in Jining, China.

Introduction: Healthcare utilization in China decreased precipitously during the initial outbreak of the COVID-19 pandemic, and women were disproportionately affected. As the COVID-19 pandemic has proven to be far more pervasive and persistent than many first surmised, a vital question is whether the utilization of non-COVID related healthcare has remained low under China's dynamic zero-COVID policy. This study aimed to estimate the initial and enduring collateral effects of the COVID-19 pandemic on the utilization of obstetrics and gynecology care at a tertiary hospital in Jining, Shandong Province, China.

Competitive evaluation and multi-stage planning of park integrated energy systems.

Optimal planning for the park integrated energy system (PIES) is essential for energy efficiency improvement and carbon neutrality. A reasonable evaluation method is the key to guide PIES planning. However, indicators for the PIES planning schemes are various with high penetration of renewable energy, large carbon emissions and multiple energy forms coupling, which brings challenges to find out the benchmark planning scheme for PIES development.

The self-fluorescence verification and intracellular imaging of nanocrystals imbedded with aggregation-induced emission luminescent materials.

Understanding cellular uptake and intracellular dissolution of drug nanocrystals is necessary. Due to their superior sensitivity, luminescent materials with aggregation-induced emission (AIE) are embedded into drug nanocrystals (hybrid nanocrystals) as a good strategy for tracking intact nanocrystals in cells. However, AIE materials are strongly hydrophobic and tend to self-aggregate, generating fluorescent interference.

Crop root bacterial and viral genomes reveal unexplored species and microbiome patterns.

Reference genomes of root microbes are essential for metagenomic analyses and mechanistic studies of crop root microbiomes. By combining high-throughput bacterial cultivation with metagenomic sequencing, we constructed comprehensive bacterial and viral genome collections from the roots of wheat, rice, maize, and Medicago. The crop root bacterial genome collection (CRBC) significantly expands the quantity and phylogenetic diversity of publicly available crop root bacterial genomes, with 6,699 bacterial genomes (68.

Residual Al Adatoms Driven Epitaxy of AlGaN QWs for High-Performance UV LEDs.

AlGaN-based ultraviolet (UV) light-emitting diodes (LEDs) experience a notable reduction in efficiency within the 280-330 nm wavelength range, known as the "UVB gap". Given the extensive applications of UV LEDs in this wavelength range, it is imperative to bridge this efficiency gap. In this study, a strategy facilitated by the presence of residual Al adatoms is introduced to simultaneously improve the integration of Ga-adatoms and the migration of Al/Ga-adatoms during the growth of low-Al-composition AlGaN quantum wells (QWs) even at high temperatures comparable to those used for high-Al-composition AlGaN quantum barriers.

Predictive value of early neutrophil-to-lymphocyte ratio and C-reactive protein in pediatric steroid-sensitive nephrotic syndrome.

Objective: This study aims to investigate the predictive value of early neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP) levels for relapse and adverse prognosis within one year in children diagnosed with steroid-sensitive nephrotic syndrome (SSNS).

Methods: This study included a total of 145 pediatric patients diagnosed with steroid-sensitive nephrotic syndrome (SSNS) between January 2016 and December 2021. We collected early neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP) levels, along with relevant clinical data, and conducted a one-year follow-up of the patients.

TREM2 Modulates Postoperative Cognitive Function in Aged Mice by Inhibiting the NLRP3/caspase-1 Pathway and Apoptosis via PLCγ2 Activation.

Postoperative cognitive dysfunction (POCD) is a prevalent complication in elderly patients, with neuroinflammation identified as a key contributing factor. This study investigates the therapeutic potential of the TREM2-PLCγ2 signaling pathway in mitigating neuroinflammation, neuronal apoptosis and cognitive impairment following surgery. We employed both in vivo and in vitro models to investigate the effects of TREM2 activation and its interaction with PLCγ2.

Optimization of sterilization efficiency for medical surgical blades in gamma irradiation using the Monte Carlo method.

Sterilizing high-carbon steel medical surgical blades is crucial for public health and safety. To enhance the sterilization efficiency of medical surgical blades, we used the Monte Carlo simulation method to study the effects of gamma irradiation sterilization parameters on high-carbon steel samples. Results show that the time required for irradiation sterilization can be decreased to 23.

The Role of Mitochondrial DNA Copy Number in Venous Thromboembolism: Insights from a 2-Sample Mendelian Randomization Study.

Background: Venous thromboembolism (VTE), including pulmonary embolism (PE) and deep vein thrombosis (DVT), is the third most common cardiovascular disease. A low amount of mitochondrial DNA copy number (mtDNA-CN) reflects mitochondrial dysfunctions and has been associations with arterial cardiovascular diseases. However, the role of mtDNA-CN in venous cardiovascular disease was unclear.

Using network analysis to identify central symptoms of depression and anxiety in different profiles of infertility patients.

Background: Depression and anxiety were not only common but also with serious consequence in infertility patients. The current study endeavors to define distinct depression and anxiety profiles of infertility patients and identify central symptoms within different profiles to facilitate targeted interventions.

Method: The research employed K-means Clustering to delineate the depression and anxiety profiles, followed by a repetition of the analysis using Latent Class Analysis (LCA).

Innate immune system signaling and intestinal dendritic cells migration to the brain underlie behavioral changes after microbial colonization in adult mice.

Background And Aims: Accumulating evidence suggests the microbiota is a key factor in Disorders of Gut-Brain Interaction (DGBI), by affecting host immune and neural systems. However, the underlying mechanisms remain elusive due to their complexity and clinical heterogeneity of patients with DGBIs. We aimed to identify neuroimmune pathways that are critical in microbiota-gut-brain communication during de novo gut colonization.

The bidirectional matter transfer in adsorption-promoted photocatalytic ozonation system derived by triazine nanosheets-heptazine nanotubes homojunction composite biochar.

Heterogeneous catalytic ozonation (HCO) process is an efficiency and eco-friendly solution to the growing challenge of water purification, yet is challenging by O utilization, pollutants selectivity, and matter transfer resistance. Herein, adsorption-promoted photocatalytic ozonation (HCO/PO) system was constructed derived by triazine nanosheets-heptazine nanotubes homojunction carbon nitride composite Enteromorpha prolifera derived biochar (CN/EpC) to provide a targeted solution for the refractory organic pollutants treatment. In the HCO/PO system, the adsorption sites predominantly reside on EpC, while the catalytic sites are primarily located on CN.

Elevated Cerebrospinal Fluid Total Tau in Niemann-Pick Disease Type C1: Correlation With Clinical Severity and Response to Therapeutic Interventions.

Niemann-Pick disease, type C1 (NPC1) is an inborn error of intracellular cholesterol transport. Impaired function of NPC1 leads to endolysosomal accumulation of unesterified cholesterol, which results in progressive neurodegeneration. Although the age of onset is variable, classical NPC1 is a pediatric disease.

Characteristics of Retina, Choroid, and Retrobulbar Blood Flow in Myopes With Posterior Staphyloma Using Ultra-Widefield OCTA and CDI.

Purpose: To explore the characteristics of retinal, choroidal, and retrobulbar blood flows in myopic patients with posterior staphyloma (PS) using ultra-widefield optical coherence tomography angiography (UWF-OCTA) and Color Doppler imaging (CDI).

Methods: The retrospective cross-sectional study enrolled 134 adults with high myopia from the Eye and ENT Hospital of Fudan University from December 2021 to September 2022. After propensity score matching, 45 eyes of 30 patients and 45 eyes of 32 patients were included in the PS and non-PS (NPS) groups, respectively.

Comparative Study of Vault Measurement by Pentacam, Casia2, and RTVue in Myopic Eyes After Implantable Collamer Lens Implantation.

Purpose: To compare vault measurement using Pentacam (Oculus, Germany) and two optical coherence tomography (OCT) instruments, Casia2 (Tomey Corporation, Japan) and RTVue (Optovue Inc. USA).

Methods: This comparative study recruited 95 eyes of 50 patients (mean age: 28.

KRM2 promotes renal cell carcinoma progression and inhibits ferroptosis by interacting with ATF2.

The role of kringle-containing transmembrane protein 2 (KRM2) in renal cell carcinoma (RCC) remains unknown. This study aimed to explore KRM2's mechanistic role in regulating RCC progression. Tissue microarrays were used to map KRM2 expression in tumor tissues and analyze its relationship with RCC clinical features.

Effects of mesenchymal stem cells on repair of injured endometrium in mice.

Endometrial damage severely affects women's reproductive health and function. Although various treatments are available, their efficacy remains generally unsatisfactory. Mesenchymal stem cells (MSCs) possess multidirectional differentiation abilities and immunoregulation.

Chronic Cutaneous and Mucosal Mucormycosis: as a Major Pathogenic Fungus.

Chronic cutaneous mucormycosis is a rare condition distinct from the acute form, characterized by a prolonged, indolent course and varied clinical presentations. This study presents a 5-year experience from a tertiary dermato-mycology clinic, identifying six cases, the majority of whom were immunocompetent, with trauma history reported in four patients. The median duration from symptom onset to diagnosis was 60 months.

Microglial repopulation alleviates surgery-induced neuroinflammation and cognitive impairment in a ZEB1-dependent manner.

Microglia play a crucial role in postoperative cognitive dysfunction (POCD). This study investigated the effects of microglial depletion and subsequent repopulation on POCD and its underlying mechanisms. An aged mouse model of POCD was induced by partial hepatectomy, and the colony-stimulating factor 1 receptor (CSF1R) inhibitor PLX5622 was administered to facilitate microglial depletion and repopulation.