Phenome-wide investigation of bidirectional causal relationships between major depressive disorder and common human diseases.

The high comorbidity of major depressive disorder (MDD) with other diseases has been well-documented. However, the pairwise causal connections for MDD comorbid networks are poorly characterized. We performed Phenome-wide Mendelian randomization (MR) analyses to explore bidirectional causal associations between MDD (N = 807,553) and 877 common diseases from FinnGen datasets (N = 377,277).

DBS in the restoration of motor functional recovery following spinal cord injury.

The landscape of therapeutic deep brain stimulation (DBS) for locomotor function recovery is rapidly evolving. This review provides an overview of electrical neuromodulation effects on spinal cord injury (SCI), focusing on DBS for motor functional recovery in human and animal models. We highlight research providing insight into underlying cellular and molecular mechanisms.

Novel Insights Into the Causal Effects and Shared Genetics Between Body Fat and Parkinson Disease.

Aims: Existing observational studies examining the effect of body fat on the risk of Parkinson disease (PD) have yielded inconsistent results. We aimed to investigate this causal relationship at the genetic level.

Methods: We employed two-sample Mendelian randomization (TSMR) to investigate the causal effects of body fat on PD, with multiple sex-specific body fat measures being involved.

Lenvatinib, sintilimab combined interventional treatment bevacizumab, sintilimab combined interventional treatment for intermediate-advanced unresectable hepatocellular carcinoma.

Background: Bevacizumab and sintilimab combined interventional treatment (BeSiIT) and L envatinib and sintilimab combined interventional treatment (LeSiIT) are two commonly used therapeutic regimens for intermediate-advanced hepatocellular carcinoma (HCC) in clinical practice.

Aim: To compare the clinical efficacy and safety of BeSiIT and LeSiIT for the treatment of intermediate and advanced HCC.

Methods: Patients diagnosed with intermediate-advanced HCC and initially treated with BeSiIT or LeSiIT in the Tianjin Medical University Cancer Institute and Hospital between February 2020 and July 2021 were included.

Mendelian randomization analysis of causal and druggable circulating inflammatory proteins in schizophrenia.

Background: Schizophrenia (SZ) is a severe mental disorder with complex origins. Observational studies suggested that inflammatory factors may play a role in the pathophysiology of SZ and we aim to investigate the potential genetic connection between them by examining the causal impact of circulating inflammatory proteins on SZ.

Methods: We utilized Mendelian randomization (MR) analysis to assess the causal relationship between circulating inflammatory proteins and SZ and the GWAS summary datasets were sourced from public databases.

Antidepressants account for the causal effect of major depressive disorder on type 2 diabetes.

Background: Patients with major depressive disorder (MDD) face an elevated risk of type 2 diabetes (T2D). However, the contribution of the disease itself versus the side effects of antidepressants to this increased risk remains unclear.

Objective: This study aimed to investigate the overall and independent effects of MDD and exposure to antidepressants on T2D risk.

Metabolic network rewiring and temperature-dependent regulation for enhanced 3-dehydroshikimate production in Escherichia coli.

The cyclohexane organic acid 3-dehydroshikimate (DHS) has potent antioxidant activity and is widely utilised in chemical and pharmaceutical industries. However, its production requires a long fermentation with a suboptimal yield and low productivity, and a disproportionate growth-to-production ratio impedes the upscaling of DHS synthesis in microbial cell factories. To overcome these limitations, competing and degradation pathways were knocked-out and key enzymes were balanced in an engineered Escherichia coli production strain, resulting in 12.

Altered functional connectivity of primary olfactory cortex-hippocampus-frontal cortex in subjective cognitive decline during odor stimulation.

Subjective cognitive decline (SCD) is a high-risk population in the preclinical stage of Alzheimer's disease (AD), and olfactory dysfunction is a risk factor for dementia progression. The present study aimed to explore the patterns of functional connectivity (FC) changes in the olfactory neural circuits during olfactory stimulation in SCD subjects. A total of 56 SCD subjects and 56 normal controls (NCs) were included.

Synthesis and characterization of selenium nanoparticles stabilized by Grifola frondosa polysaccharides and gallic acid conjugates.

Selenium nanoparticles (SeNPs) are of interest for their versatility and low toxicity, but bare SeNPs are unstable and tend to aggregate and precipitate as black elemental Se, which limits the application of SeNPs. This study evaluated the physicochemical properties, physical stability, antioxidant activities and cytotoxicity of SeNPs stabilized by Grifola frondosa polysaccharides (GFPs) and GFPs-gallic acid conjugates (GFPs-GA). The results showed that the particle size (PZ), polymer index (PDI) and zeta potential (ZP) of the GFPs-SeNPs and GFPs-GA-SeNPs were 58.

Identification of PANoptosis-relevant subgroups and predicting signature to evaluate the prognosis and immune landscape of patients with biliary tract cancer.

Background: This study conducted molecular subtyping of biliary tract cancer patients based on 19 PANoptosis-related gene signatures.

Methods: Through consensus clustering, patients were categorized into two subtypes, A and B. By integrating multi-omics data and clinical information from different cohorts, we elucidated the association between different subtypes of biliary tract cancer and patient prognosis, which correlated with the immune infiltration characteristics of patients.

DNAJC24 acts directly with PCNA and promotes malignant progression of LUAD by activating phosphorylation of AKT.

Heat shock proteins (HSPs) are a group of highly conserved proteins found in a wide range of organisms. In recent years, members of the HSP family were overexpressed in various tumors and widely involved in oncogenesis, tumor development, and therapeutic resistance. In our previous study, DNAJC24, a member of the DNAJ/HSP40 family of HSPs, was found to be closely associated with the malignant phenotype of hepatocellular carcinoma.

Quantitative and Qualitative Parameters of DCE-MRI Predict CDKN2A/B Homozygous Deletion in Gliomas.

Rationale And Objectives: Homozygous deletion (HD) of CDKN2A/B holds important prognostic value in gliomas. This study aimed to explore the predictive potential of conventional MRI characteristics combined with dynamic contrast-enhanced MRI parameters in predicting CDKN2A/B HD status in gliomas.

Materials And Methods: Preoperative MRI data of 105 patients (69 without CDKN2A/B HD, and 36 with CDKN2A/B homozygous deletion) with gliomas were retrospectively collected.

Olfactory deficit: a potential functional marker across the Alzheimer's disease continuum.

Alzheimer's disease (AD) is a prevalent form of dementia that affects an estimated 32 million individuals globally. Identifying early indicators is vital for screening at-risk populations and implementing timely interventions. At present, there is an urgent need for early and sensitive biomarkers to screen individuals at risk of AD.

Alleviation of Rheumatoid Arthritis by Inducing IDO Expression with Recombinant Protein 43.

Rheumatoid arthritis (RA) represents the autoimmune disorder that shows aggressive arthritis as the main symptom. It is difficult to treat and can lead to joint deformation and function loss. At present, () antigen has attracted much attention because it plays a role in host immune regulatory mechanisms.

Sintilimab, bevacizumab biosimilar, and HAIC for unresectable hepatocellular carcinoma conversion therapy: a prospective, single-arm phase II trial.

We assessed the efficacy and safety of sintilimab [an anti-programmed death (PD-1)] plus bevacizumab biosimilar (IBI305), and hepatic arterial infusion chemotherapy (HAIC) in patients with unresectable hepatocellular carcinoma (HCC). The patients received sintilimab (200 mg) plus IBI305 (7.5 mg/kg) and HAIC (FOLFOX for 23 h) and were treated every 3 weeks.

ELONGATED HYPOTCOTYL5 and SPINE BASE SIZE1 together mediate light-regulated spine expansion in cucumber.

Plant trichome development is influenced by diverse developmental and environmental signals, but the molecular mechanisms involved are not well understood in most plant species. Fruit spines (trichomes) are an important trait in cucumber (Cucumis sativus L.), as they affect both fruit smoothness and commercial quality.

Retroperitoneoscopic Clampless, Sutureless Hybrid Therapy in the Management of Renal Hilar Tumors.

Objective: We aimed to investigate the outcomes and feasibility of a retroperitoneoscopic clampless, sutureless hybrid technique in the management of renal hilar tumors.

Methods: A retrospective cohort of consecutive patients with renal hilar tumors who received retroperitoneoscopic clampless, sutureless hybrid therapy between January 2017 and April 2021 was included. The hybrid surgical technique involved microwave ablation (MWA), followed by clampless tumor enucleation and sutureless hemostasis.

A Minireview of the Solid-State Electrolytes for Zinc Batteries.

Aqueous zinc-ion batteries (ZIBs) have gained significant recognition as highly promising rechargeable batteries for the future due to their exceptional safety, low operating costs, and environmental advantages. Nevertheless, the widespread utilization of ZIBs for energy storage has been hindered by inherent challenges associated with aqueous electrolytes, including water decomposition reactions, evaporation, and liquid leakage. Fortunately, recent advances in solid-state electrolyte research have demonstrated great potential in resolving these challenges.

PdMo Bimetallene Coupled with MXene Nanosheets as Efficient Bifunctional Electrocatalysts for Formic Acid and Methanol Oxidation Reactions.

In this study, we demonstrate a facile soft chemistry strategy for the growth of two-dimensional (2D) ultrathin PdMo bimetallene tightly coupled with TiCT MXene nanosheets (PdMo/TiCT) using a robust stereoassembly process. The 2D PdMo bimetallene offers numerous unsaturated Pd atoms and simultaneously induces combined bimetallic alloy and strain effects, while the TiCT matrix effectively optimizes the electronic structure of PdMo bimetallene via a face-to-face interface interaction and guarantees exceptional electrical conductivity. As a consequence, the newly designed PdMo/TiCT nanoarchitecture expresses remarkable electrocatalytic properties for the formic acid and methanol electro-oxidation, in terms of large electrochemically active surface areas, ultrahigh catalytic activity, strong antipoisoning ability, and dependable long-term stability, all of which are better than those of conventional Pd nanoparticle catalysts supported by TiCT and carbon matrices.

Achieving High-Performance Electrocatalytic Water Oxidation on Ni(OH) with Optimized Intermediate Binding Energy Enabled by S-Doping and CeO -Interfacing.

The adsorption energy of the reaction intermediates has a crucial influence on the electrocatalytic activity. Ni-based materials possess high oxygen evolution reaction (OER) performance in alkaline, however too strong binding of *OH and high energy barrier of the rate-determining step (RDS) severely limit their OER activity. Herein, a facile strategy is shown to fabricate novel vertical nanorod-like arrays hybrid structure with the interface contact of S-doped Ni(OH) and CeO in situ grown on Ni foam (S-Ni(OH) /CeO /NF) through a one-pot route.

Construction and application of a new watermelon germplasm with the phenotype of dwarf and branchless.

Watermelon (Citrullus lanatus) is a widely cultivated cucurbitaceae crop appreciated by consumers worldwide. However, the long vine and abundant lateral branches of currently cultivated watermelon varieties hinder light simplification and mechanized cultivation, affecting plant spacing and row spacing requirements. To address this, the development of watermelon with dwarf and branchless traits has become a crucial direction for the industry.

Effect of Additional Mass on Natural Frequencies of Weight-Sensing Structures.

The phenomena of variability and interference in the natural frequencies of weight-sensing structures applied in complex working conditions must solve the problem of reducing or eliminating resonance under low-frequency vibrations to maximize stability, accuracy and reliability. The influence laws of the additional mass with relevant characteristics on the natural frequencies, which include the components of mass, stiffness and center-of-mass distribution, etc. Firstly, the theoretical formulas of the mathematical model are given based on different characteristics of the weight-sensing structure, and various combinations of additional masses on the weight-sensing structures are adjusted in the X-, Y-, and Z-directions.

Natural allelic variation in the EamA-like transporter, CmSN, is associated with fruit skin netting in melon.

A SNP mutation in CmSN, encoding an EamA-like transporter, is responsible for fruit skin netting in melon. In maturing melon (Cucumis melo L.), the rind becomes reticulated or netted, a unique characteristic that dramatically changes the appearance of the fruit.