Preparation of Hybrid Molecularly Imprinted Polymers Based on 3-Triethoxysilylpropyl Methacrylic Amide for Solid-Phase Extraction of Gatifloxacin From Lake Water.

A novel molecularly imprinted polymer (MIP) against gatifloxacin based on a hybrid monomer (3-triethoxysilylpropyl methacrylic amide, APTES-MAA) was reported. In this study, the imprinted monolith was synthesized with gatifloxacin as template, ethylene glycol dimethacrylate (EGDMA) as cross-linker, and APTES-MAA as functional monomer in a mixture of acetonitrile and isooctane as porogen via an optimization based on density functional theory (DFT). The polymers were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, and mercury porosimetry.

Intraoperative isotonic balanced versus hypotonic crystalloids on postoperative sodium homeostasis in small children undergoing major neurosurgery: a randomized controlled trial.

Background: Whether intraoperative isotonic balanced maintenance fluid is associated with less variation in sodium homeostasis in small children undergoing major neurosurgery remains unknown.

Methods: Patients aged up to 6 years undergoing major neurosurgery were randomly assigned to receive either isotonic balanced solution (IB) or 0.2% hypotonic solution (H) as intraoperative maintenance fluid.

Smoking negatively impacts ocular surface health and corneal nerve metrics.

Purpose: To evaluate the effects of smoking on ocular surface through comprehensive analysis of corneal nerves, corneal epithelium, dendritic cells (DCs), and clinical assessments.

Methods: This cross-sectional study included 250 healthy smokers and 272 healthy non-smokers. Patients' smoking status and duration were recorded.

The PM2.5 component, benzo[b]fluoranthene, may contribute to the pathogenesis of membranous nephropathy by activating phosphoinositide 3-kinase/protein kinase B pathway and causing podocyte pyroptosis.

Membranous nephropathy (MN) is the main type of adult nephrotic syndrome, and its prevalence is increasing annually. An increasing number of studies have suggested that the pathogenesis of MN is related to 2.5-μm particulate matter (PM2.

Favorable Cerebral Collateral Cascades Improve Futile Recanalization by Reducing Ischemic Core Volume in Acute Ischemic Stroke Patients Undergoing Endovascular Treatment.

Although endovascular treatment (EVT) was the first-line therapeutic strategy for acute ischemic stroke (AIS), half of the patients could not achieve functional independence. Previous studies suggested arterial collateral was an important predictor of this phenomenon. However, cerebral collateral circulation was regulated by arteries, venous, and microcirculation, and its role remained unclear.

Case Report: Dual-chamber pacemaker for hypertrophic cardiomyopathy with bradyarrhythmia and idiopathic pericardial effusion: a report of two cases and literature review.

Background: Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disorder characterized by asymmetric hypertrophy of the ventricles and the ventricular septum, leading to subsequent left ventricular outflow tract (LVOT) obstruction and diastolic dysfunction. Typically, patients with HCM experience sinus tachycardia and sinus arrest relatively infrequently. In addition, the concurrent occurrence of HCM with non-surgically induced (ablation or myectomy) bradyarrhythmia and idiopathic pericardial effusion in adult patients has not been previously reported.

Impact of self-reported SARS-CoV-2 antibody positivity on cardiac structure and function: findings from UK Biobank CMR cohort.

Background: SARS-CoV-2 antibody positivity, whether due to natural infection or vaccination, is known to be associated with specific cardiac and vascular damage, yet its impact on cardiac structure and function in prospective cohorts remains incompletely understood.

Objective: We aimed to assess cardiac changes in the UK Biobank cohort among individuals with self-reported seropositive results for SARS-CoV-2 antibodies.

Methods: UK Biobank participants with self-reported serological results for SARS-CoV-2 antibodies, who underwent their first cardiac magnetic resonance (CMR) scan after 2019 were included.

Personality perspective on depression and anxiety symptoms among Chinese adolescents and young adults: a two-sample network analysis.

Background: The mental health burden among adolescents has been increasing, impacting individuals even before formal diagnosis of common mental disorders. Although personality traits, as key indicators of mental health conditions, play a crucial role in the development of mental disorders, there is a gap regarding the trait-to-symptom pathways and similarities and differences between adolescents and young adults.

Methods: A total of 860 adolescents and 1751 young adults participated in this study.

SMYD3 Activates Fatty Acid β-oxidation to Promote Self-Renewal of Leukemia Stem Cells.

The development of BCR-ABL tyrosine kinase inhibitors (TKIs) has revolutionized disease management of chronic myeloid leukemia (CML). However, the persistence of leukemia stem cells (LSCs) remains a major barrier to curing CML, highlighting the urgent need to identify the regulators supporting LSCs. In this study, we validated the critical role of the histone methyltransferase SET and MYND domain containing 3 (SMYD3) in the maintenance of LSCs in CML.

Prediction and Experimental Study of Low-Frequency Acoustic and Vibration Responses for an Aircraft Instrument Compartment Based on the Virtual Material Method.

Bolted connections are extensively utilized in aircraft structures, and accurately simulating these connections is a critical factor affecting the precision of vibration and noise response predictions for aircraft. This study focuses on an instrument compartment of a specific aircraft model, employing the virtual material method to simulate the bolted joints within the structure. Parameters for the virtual material layer were obtained through theoretical calculations combined with parameter identification methods, achieving precise modeling of the instrument compartment.

Effect of Poly (Caprolactone) Introduction Site on the Network Structure and Properties of Glycidyl Azide Polymer Adhesive.

Copolymers of glycidyl azide polymer (GAP) and poly (caprolactone) (PCL) were obtained by introducing PCL molecular chains at both ends or side groups of GAP molecular chains, respectively. GAP/PCL elastomers were prepared via polyurethane curing reaction and compared with GAP/PCL elastomers prepared by physical blending, in order to clarify the relationship between microstructure and macroscopic properties. The results showed that no GAP and PCL phase separation was observed in the chemically bonded GAP/PCL elastomers.

Effect of Hard-Segment Structure on the Properties of Polyurethane/Poly(Ethyl Methacrylate) Damping Composites.

Damping material performance influences the efficacy of vibration and noise reduction. However, traditional damping materials often have low damping peaks or narrow damping temperature ranges. In this study, a series of polyurethane (PU)/poly(ethylene methacrylate) (PEMA) composites were synthesised, in which the PU hard segments were varied using toluene diisocyanate (TDI), diphenylmethane diisocyanate (MDI), isophorone diisocyanate (IPDI), and hexamethylene diisocyanate.

Seven novel sesquiterpenes with hemostasis activities from leaves of Callicarpa nudiflora.

A pair of epimer with an unprecedented 4/7/6 tricyclic skeleton sesquiterpene (1 and 2) and five novel sesquiterpene (3-7) were isolated from Callicarpa nudiflora Hook. et Arn. Their structures were established by extensive spectroscopic analyses, single crystal X-ray diffraction, experimental electronic circular dichroism (ECD) spectra comparison and DP4+ probability analysis.

FAP-catalyzed in situ self-assembly of magnetic resonance imaging probe for early and precise staging of liver fibrosis.

Liver fibrosis is an inevitable stage in the progression of most chronic liver diseases. Early diagnosis and treatment of liver fibrosis are crucial for effectively managing chronic liver conditions. However, there lacks a noninvasive and sensitive imaging method capable of early assessing fibrosis activity.

Applications and Predictors of Outcomes Following Stereo-Electroencephalography in Pediatric Patients With Drug-Resistant Epilepsy.

Aims: This study aims to evaluate the role of stereo-electroencephalography (SEEG) in managing pediatric patients with drug-resistant epilepsy. We further explore prognostic factors influencing surgical outcomes following SEEG-guided resective or disconnective surgery.

Methods: A retrospective review was conducted on pediatric patients who underwent SEEG at the Pediatric Epilepsy Center, Peking University First Hospital, between July 2017 and July 2022.

Flavonoids as key players in cold tolerance: molecular insights and applications in horticultural crops.

Cold stress profoundly affects the growth, development, and productivity of horticultural crops. Among the diverse strategies plants employ to mitigate the adverse effects of cold stress, flavonoids have emerged as pivotal components in enhancing plant resilience. This review was written to systematically highlight the critical role of flavonoids in plant cold tolerance, aiming to address the increasing need for sustainable horticultural practices under climate stress.

Effects of exogenous calcium on seed germination and physiological traits of alfalfa (Medicago sativa) seedlings.

To enhance the cultivation and utility of alfalfa (Medicago sativa) in calcium-rich environments, we assessed the germination, growth, and physiological responses of seven alfalfa varieties-Crown, Dieter, PANGO, Gladiator, Victoria, WL525, and Magnum 801-under varying calcium chloride (CaCl) concentrations (0, 5, 25, and 50 mmol·L). Germination indices, root and shoot growth, enzyme activities, and osmotic regulation parameters were analyzed to evaluate adaptive responses to calcium stress. Our results showed that alfalfa adapts to calcium stress by increasing root length, enhancing enzyme activities, regulating osmotic substance content, and reducing malondialdehyde levels, thereby striving to maintain stable dry matter content.

Tracking In Vivo Lipolysis of Lipid Nanocarriers Using NIR-II Polarity-Sensitive Fluorescent Probes.

Elucidating in vivo lipolysis is crucial for clarifying the underlying mechanisms and in vivo fates of lipid-based nanocarriers, which are essential oral drug delivery carriers. Current mainstream methodologies use various in vitro digestion models to predict the in vivo performance of lipid formulations; however, their accuracy is often impeded by the complicated environment of the gastrointestinal tract. Although fluorescence labeling with conventional probes partly reveals the in vivo translocation of lipid nanocarriers, it fails to elucidate the lipolysis process because of poor signal discrimination among nanocarriers, free probes, and mixed micelles (lipolysis end-products).

Probing the Structural Elements of Polysaccharide Adjuvants for Enhancing Respiratory Mucosal Response: From Surmounting Multi-Obstacles to Eliciting Cascade Immunity.

The immunomodulatory effects and excellent tolerability of polysaccharides make them optimal candidates for pulmonary vaccine adjuvants. Yet, the structure-immunostimulatory activity relationship of polysaccharides remains unrevealed. Here, we developed nanovaccines decorated with four polysaccharides of distinct structures─hyaluronic acid (HA), pectin (PC), chondroitin sulfate (SC), and heparan sulfate (SH)─all sharing similar particle sizes and zeta potential.

A quality assessment algorithm for no-reference images based on transfer learning.

Image quality assessment (IQA) plays a critical role in automatically detecting and correcting defects in images, thereby enhancing the overall performance of image processing and transmission systems. While research on reference-based IQA is well-established, studies on no-reference image IQA remain underdeveloped. In this article, we propose a novel no-reference IQA algorithm based on transfer learning (IQA-NRTL).

The Effects of M2 Macrophages-Derived Exosomes on Urethral Fibrosis and Stricture in Scar Formation.

Background: Macrophages are highly plastic cells, and macrophage-derived exosomes (M-Exos) have been implicated in inflammation-related pathophysiologies, such as tissue injury and fibrosis repair. This study aimed to investigate the possible effects of M-Exos on the initiation and development of urethral fibrosis and stricture after injury, and to elucidate the underlying mechanisms.

Methods: In this study, we used time-tracking immunofluorescence staining for M1 and M2 macrophage markers to characterize sequential properties in the site of injured urethra.

Wearable photobiomodulation halts thyroid cancer growth by leveraging thyroid photosensitivity.

With papillary thyroid carcinoma (PTC) rates rising significantly, concerns about conventional treatments like thyroidectomy and radiotherapy highlight the need for non-invasive options. Our study explores photobiomodulation therapy (PBMT), which uses specific light wavelengths to evoke cellular responses in PTC treatment. Our research utilized a custom-designed optical system to investigate PBMT, finding that blue light at a wavelength of 465 nm can safely and effectively inhibit the proliferation of the TPC-1 PTC cell line by inducing cell cycle arrest.

Biomineralize Mitochondria in Metal-Organic Frameworks to Promote Mitochondria Transplantation From Non-Tumorigenic Cells Into Cancer Cells.

Mitochondria are crucial to cellular physiology, and growing evidence highlights the significant impact of mitochondrial dysfunction in diabetes, aging, neurodegenerative disorders, and cancers. Therefore, mitochondrial transplantation shows great potential for therapeutic use in treating these diseases. However, transplantation process is notably challenging due to very low efficiency and rapid loss of bioactivity post-isolation, leading to poor reproducibility and reliability.

Comparative Effectiveness of Different Opioid Regimens, in Daily Dose or Treatment Duration, Prescribed at Surgical Discharge: a Systematic Review and Meta-Analysis.

Background: Opioids are prescribed for postsurgical pain management, but a balance between achieving adequate pain control and minimising opioid-related harm is required. This study aimed to investigate the effectiveness of different opioid regimens, in daily dose or treatment duration, prescribed at surgical discharge.

Methods: A systematic search of MEDLINE, EMBASE, CENTRAL, and ICTRP was performed from inception to 12 January 2025.

The impact of restricted community accessibility on needle and syringe sharing among drug users in Baise city: based on the event study method.

Objective: To investigate the effect of the restricted access to clean needles and syringes on needle and syringe sharing behavior like Human Immunodeficiency Virus (HIV) and Hepatitis C Virus (HCV) amongst the people who inject drugs (PWID) in Baise, Guangxi province of China, and to provide the scientific evidence for formulating public health policies aimed at preventing HIV transmission.

Method: Using the national unified questionnaire and plan, from 2010 to 2019, snowball sampling was conducted among the community drug users under sentinel surveillance in Baise City's county districts every April to June. During face-to-face interviews with each participant, a structured questionnaire was used to collect demographic, behavioral, and venous blood for serological surveillance.