Activation of Wnt/β-catenin signaling is involved in hair growth-promoting effect of 655-nm red light and LED in in vitro culture model.

Activation of the Wnt/β-catenin signaling pathway plays an important role in hair follicle morphogenesis and hair growth. Recently, low-level laser therapy (LLLT) was evaluated for stimulating hair growth in numerous clinical studies, in which 655-nm red light was found to be most effective and practical for stimulating hair growth. We evaluated whether 655-nm red light + light-emitting diode (LED) could promote human hair growth by activating Wnt/β-catenin signaling.

MiR-22 suppresses epithelial-mesenchymal transition in bladder cancer by inhibiting Snail and MAPK1/Slug/vimentin feedback loop.

MicroRNAs (miRNAs) have been validated to play prominent roles in the occurrence and development of bladder cancer (BCa). MiR-22 was previously reported to act as a tumor suppressor or oncomiRNA in various types of cancer. However, its accurate expression, function, and mechanism in BCa remain unclear.

Is Achillon repair safe and reliable in delayed presentation Achilles tendon rupture? A five-year follow-up.

Background: To assess the outcome of delayed repair of ruptured Achilles tendon using the Achillon mini-open technique.

Methods: A review of all patients who underwent delayed repair (>10 days post injury) of ruptured Achilles tendon with mini invasive technique was compared to acute repairs carried out at the same unit. Leppilahti Score and Achilles Tendon Total Rupture Score (ATRS) were utilised.

Innovative endoscopic enucleations of the prostate - Xie's Prostate Enucleations.

In the past 2 decades, endoscopic enucleation of the prostate has become a safe and effective surgical treatment for benign prostatic hyperplasia (BPH), with comparable outcomes to traditional surgeries. Transurethral vapor enucleation and resection of the prostate (TVERP), transurethral vapor enucleation of the prostate (TVEP), and ultrasound-navigated TVEP (US-TVEP) are new, innovative endoscopic enucleation procedures. These procedures are named Xie's Prostate Enucleations (Xie's Procedures for short).

Ultrafine and Ligand-Free Precious Metal (Ru, Ag, Au, Rh and Pd) Nanoclusters Supported on Phosphorus-Doped Carbon.

We report the use of phosphorus-doped carbon (P-C) as support to grow ultrasmall (1-3 nm) and ligand-free precious metal nanocrystals (PMNCs) via chemical reduction. We show that the valence states of surface phosphorus species are critical in tuning the affinity between the carbon support and metal precursors, which rationally controls the loading size and uniformity of resultant PMNCs. Five kinds of PMNCs, including Ru, Ag, Au, Rh, and Pd, were grown in situ to demonstrate the key role of surface phosphorus sites on the P-C support.

Beaten Into Submissiveness? An Investigation Into the Protective Strategies Used by Survivors of Domestic Abuse.

The aim of the study was to identify the prevalence and perceived helpfulness of a variety of protective strategies that were used by female survivors of domestic abuse and to explore factors that may have influenced strategy usage. Forty participants were recruited from a voluntary sector domestic abuse service, commissioned by an outer London local authority in the United Kingdom, in early 2014. The measurement tools used were the Intimate Partner Violence Strategies Index (IPVSI) and the Coordinated Action Against Domestic Abuse (CAADA) Domestic Abuse, Stalking and "Honour"-Based Violence (DASH) Risk Assessment Checklist.

The Levels and Potential Carcinogenic Risks of PAHs in Liaohe Estuarine Reed Wetland Soils.

Sixteen polycyclic aromatic hydrocarbons (PAHs) were quantified by GC/MS in 30 soil samples of Liaohe estuarine reed wetland. The total concentrations of 16 PAHs ranged from 235 to 374 ng g, and seven carcinogenic PAHs concentrations were in the range of 83-109 ng g. A probabilistic carcinogenic potential for three age groups (including children, teenagers, and adults) exposed to soil PAHs via three pathways was quantitatively calculated based on Monte Carlo simulations.

CRISPR-ON-Mediated KLF4 overexpression inhibits the proliferation, migration and invasion of urothelial bladder cancer and .

Kruppel like factor 4 (KLF4), a transcription factor associated with carcinogenesis and tumor progression, plays an important role in various malignancies. In the present study, we utilized the CRISPR-ON system to upregulate KLF4 expression level and subsequently investigated the effect and mechanism of KLF4 in the carcinogenesis and progression of urothelial bladder cancer (UBC). Immunohistochemistry (IHC) and quantitative RT-PCR (qRT-PCR) were used to evaluate the expression of KLF4.

[Comparison of national early warning score, rapid emergency medicine score and acute physiology and chronic health evaluation II score for predicting outcome among emergency severe patients].

Objective: To analyze the comparation of national early warning score (NEWS), rapid emergency medicine score (REMS) and acute physiology and chronic health evaluation II (APACHE II) score in predicting prognosis of critically ill patients in emergency department (ED).

Methods: A retrospective study was conducted. Critically ill patients, aged > 16 years, hospitalized > 24 hours, and admitted to the ED of Nanhua Hospital Affiliated to South China University from January 2016 to June 2017 were enrolled.

c-Met, CREB1 and EGFR are involved in miR-493-5p inhibition of EMT via AKT/GSK-3β/Snail signaling in prostate cancer.

miR-493-5p downregulation has emerged as a critical player in cancer progression yet, the underlying mechanisms of miR-493-5p expression pattern and its function in prostate cancer remains to be elucidated. Here, we illustrate that miR-493-5p is frequently downregulated in prostate cancer, at least partially due to altered DNA methylation. miR-493-5p functions as a tumor suppressor in prostate cancer cells.

Recombinant latcripin 11 of Lentinula edodes C91-3 suppresses the proliferation of various cancer cells.

Lentinula edodes C91-3 is an edible mushroom that has demonstrated a remarkable anti-tumor effect in various cancer cells both in vitro and in vivo. In the present study, we report the ability of recombinant thioredoxin-like latcripin 11 (LP-11) of Lentinula edodes C91-3 to suppress the proliferation of various cancer cells. The LP-11 gene of Lentinula edodes C91-3 was cloned in the pET-32a(+) expression vector and expressed in a prokaryotic system.

Synthesis of Mesoporous CoS and NiCoS with Superior Supercapacitive Performance Using a Facile Solid-Phase Sulfurization.

Synthesis of nanostructured transition metal sulfides is of particular interest in providing new methods to control their porosity and improve their surface area because those sulfides hold promising applications in high-energy density devices. Significant challenges remain currently to prepare metal sulfides having three-dimensional (3-D) continuous mesoporous structures, known to be critical for increasing their active surface sites and enhancing ion transport. We herein present a facile solid-phase sulfurization method to synthesize 3-D continuous mesoporous CoS, NiS, and their binary sulfides in a two-step nanocasting using bicontinuous KIT-6 as hard templates.

MET/SMAD3/SNAIL circuit mediated by miR-323a-3p is involved in regulating epithelial-mesenchymal transition progression in bladder cancer.

Bladder cancer (BCa) is the one of the most common cancers with high incidence, occurrence and low 5-year survival rate. Emerging evidence indicates that DLK1-DIO3 genomic region especially the miRNA cluster in this region is involved in several pathologic processes and various cancers, and miR-323a-3p is a member of this miRNA cluster. In this study, we investigate the function and regulatory network of miR-323a-3p in BCa.

Polypeptide -acetylgalactosaminyltransferase-6 expression in gastric cancer.

Gastric cancer (GC) is one of the leading causes of cancer-related deaths, with limited improvement in its clinical outcome worldwide. Aberrant mucin-type -glycosylation is a critical event widespread in the development of GC. Polypeptide -acetylgalactosaminyltransferases (GALNTs) regulate the initial step and determine the sites of mucin-type -glycoprotein bio-synthesis.

β-Catenin is involved in oleanolic acid-dependent promotion of proliferation in human hair matrix cells in an in vitro organ culture model.

Oleanolic acid (OA), a pentacyclic triterpenoid compound which can be found in >1600 plants, has been shown to promote hair growth. To study the mechanisms of OA on hair growth, we investigated hair follicle (HF) growth on four different concentration OA using human hair follicle organ culture model. We found that HFs treated with 1 or 10μg/mL OA showed statistically enhanced elongation of the hair shaft and anagen-like stage.

When to perform bone scintigraphy in patients with newly diagnosed prostate cancer? a retrospective study.

Background: To determine when a bone scintigraphy investigation is appropriate in patients with newly diagnosed prostate cancer (PCa).

Methods: We retrospectively reviewed 703 newly diagnosed PCa patients who were referred for bone scintigraphy. The association between age, prostate specific antigen (PSA), Gleason score (GS) and bone scintigraphy result were investigated by series of crude or stratified analysis.

MicroRNA-608 inhibits proliferation of bladder cancer via AKT/FOXO3a signaling pathway.

Background: Current evidence indicates that miR-608 is widely down-regulated in various malignant tumors including liver cancer, colon cancer, lung cancer and glioma, and acts as a tumor suppressor by inhibiting cell proliferation, invasion and migration or by promoting apoptosis. The specific biological function of miR-608 in bladder cancer is still unknown.

Methods: qRT-PCR and Chromogenic in Situ Hybridization (CISH) was conducted to assess the expression of miR-608 in paired BCa tissues and adjacent non-tumor bladder urothelial tissues.

Electrocatalytic Oxidation of Alcohols, Tripropylamine, and DNA with Ligand-Free Gold Nanoclusters on Nitrided Carbon.

Electrocatalytic properties of ligand-free gold nanoclusters (AuNCs, <2 nm) grown on nitrided carbon supports (denoted as AuNCs@N-C) were evaluated for the oxidation of representative organic molecules including alcohols, an amine, and deoxyguanosine in oligonucleotides. AuNCs@N-C catalysts were incorporated into films of architecture {PDDA/AuNCs@N-C} by using layer-by-layer assembly with oppositely charged poly(diallyldimethylammonium) (PDDA) on pyrolytic graphite (PG) electrodes. Cyclic voltammetry and electrochemical impedance spectroscopy (EIS) were used to survey the electrocatalytic properties of these AuNCs@N-C films.

Nanoengineering of aggregation-free and thermally-stable gold nanoparticles in mesoporous frameworks.

Loading catalytically active, aggregation-free and thermally stable metal nanoparticles (NPs) on a high surface area support represents a major interest in heterogeneous catalysis. Current synthetic approaches to these hybrid catalysts, however, still lack controllability in the thermal stability of metal NPs, particularly at high temperatures in the absence of organic ligands. We herein report a facile "co-assembly" methodology to prepare aggregation-free, ligand-free and thermally stable mesoporous hybrid nanocatalysts of metal-oxides and metal-carbons.

Apigenin inhibits renal cell carcinoma cell proliferation.

Apigenin, a natural flavonoid found in vegetables and fruits, has antitumor activity in several cancer types. The present study evaluated the effects and mechanism of action of apigenin in renal cell carcinoma (RCC) cells. We found that apigenin suppressed ACHN, 786-0, and Caki-1 RCC cell proliferation in a dose- and time-dependent manner.

Surface Engineering of Spherical Metal Nanoparticles with Polymers toward Selective Asymmetric Synthesis of Nanobowls and Janus-Type Dimers.

New synthetic methods capable of controlling structural and compositional complexities of asymmetric nanoparticles (NPs) are very challenging but highly desired. A simple and general synthetic approach to designing sophisticated asymmetric NPs by anisotropically patterning the surface of isotropic metallic NPs with amphiphilic block copolymers (BCPs) is reported. The selective galvanic replacement and seed-mediated growth of a second metal can be achieved on the exposed surface of metal NPs, resulting in the formation of nanobowls and Janus-type metal-metal dimers, respectively.

Depth of interaction determination in monolithic scintillator with double side SiPM readout.

Background: Monolithic scintillators read out by arrays of photodetectors represent a promising solution to obtain high spatial resolution and the depth of interaction (DOI) of the annihilation photon. We have recently investigated a detector geometry composed of a monolithic scintillator readout on two sides by silicon photomultiplier (SiPM) arrays, and we have proposed two parameters for the DOI determination: the difference in the number of triggered SiPMs on the two sides of the detector and the difference in the maximum collected signal on a single SiPM on each side. This work is focused on the DOI calibration and on the determination of the capability of our detector.

Sensory and autonomic function and structure in footpads of a diabetic mouse model.

Sensory and autonomic neuropathy affects the majority of type II diabetic patients. Clinically, autonomic evaluation often focuses on sudomotor function yet this is rarely assessed in animal models. We undertook morphological and functional studies to assess large myelinated and small unmyelinated axons in the db/db type II diabetes mouse model.

Ultrafine Co-based Nanoparticle@Mesoporous Carbon Nanospheres toward High-Performance Supercapacitors.

A general synthetic methodology is reported to grow ultrafine cobalt-based nanoparticles (NPs, 2-7 nm) within high-surface-area mesoporous carbon (MC) frameworks. Our design strategy is based on colloidal amphiphile (CAM) templated oxidative self-polymerization of dopamine. The CAM templates consisting of a hydrophobic silica-like core and a hydrophilic PEO shell can coassemble with dopamine and template its self-polymerization to form polydopamine (PDA) nanospheres.

miR-148a-3p represses proliferation and EMT by establishing regulatory circuits between ERBB3/AKT2/c-myc and DNMT1 in bladder cancer.

miR-148a-3p downregulation has emerged as a critical factor in cancer progression yet, the underlying mechanisms of miR-148a-3p expression pattern and its function in bladder cancer remains to be elucidated. Here, we illustrate that miR-148a-3p is frequently downregulated in bladder cancer and that its expression may be regulated by DNA methylation. DNA methyltransferase 1 (DNMT1) and miR-148a-3p function in a positive feedback loop in bladder cancer.