Oncological and Clinical Impacts of Routine Splenic Flexure Mobilization in Anterior Resection.

Background Splenic flexure mobilization (SFM) is widely regarded as one of the most challenging steps in laparoscopic and robotic colorectal surgery, sparking ongoing debate. Some surgeons routinely advocate for SFM, citing its role in achieving greater left colonic reach, which facilitates a safe, tension-free, and well-vascularized anastomosis while adhering to oncological principles. Conversely, others argue that SFM does not consistently ensure these benefits and may increase the risk of complications, including splenic, bowel, or vascular injuries, as well as unnecessarily prolonging the procedure.

Lactobacillus reuteri Assists Engineered Bacteria That Target Tumors to Release PD-L1nb to Mitigate the Adverse Effects of Breast Cancer Immunotherapy.

Programmed death protein-ligand 1 (PD-L1) inhibitors demonstrate significant antitumor efficacy by modulating T-cell activity and inhibiting the PD-1/PD-L1 pathway, thus enhancing immune responses. Despite their robust effects, systemic administration of these inhibitors is linked to severe immune toxicity. To address this issue, we engineered a strain, REP, which releases PD-L1 nanoantibodies (PD-L1nb) to treat breast cancer and attenuate immunotherapy-related side effects.

Directly anterior approach for total hip arthroplasty with an acetabular structural bone graft for developmental dysplasia of the hip (Crowe III and IV): a concise 5-year follow-up evaluation.

Background: This study evaluated the results of total hip arthroplasty (THA) via the direct anterior approach (DAA) in the lateral decubitus position combined with acetabular reconstruction via a bulk autograft for patients with developmental dysplasia of the hip (Crowe III and IV).

Patients And Methods: A retrospective study was conducted to analyse 16 patients (16 hips) with Crowe type III and IV developmental dysplasia of the hip (DDH) who underwent THA from June 2016 to July 2021. We recorded and analysed variables such as age, sex, height, body mass index (BMI), length of surgical incision, duration of surgery, intraoperative blood loss, Harris hip score, visual analogue scale (VAS) score, lower limb length, and pelvic radiograph analysis.

A Universal Solid-Phase Synthetic Strategy for Ultrafine Intermetallic Libraries Confined in Ordered Mesoporous Carbon.

Ordered intermetallic nanocatalysts supported on high-surface-area skeletons are of great importance in catalysis and have disclosed notable catalytic activity and stability that are remarkably better than their random alloy counterparts. Ultrafine intermetallic nanocatalysts are synthetically challenging, especially for universal and scaled-up synthesis, because of inevitable sintering and phase separation under high temperatures that promote atomic alloying and ordering. Herein, a universal solid-phase and scaled-up method is reported for synthesizing ultrafine intermetallic nanocatalysts with uniform size distributions and wide compositional spaces confined in ordered mesoporous carbon (OMC) supports, where the strong physical confinement and chemical interaction between metals and sulfur/mesoporous templates remarkably suppress the high-temperature sintering and phase separation even up to 1000 °C.

STAT2/SLC27A3/PINK1-Mediated Mitophagy Remodeling Lipid Metabolism Contributes to Pazopanib Resistance in Clear Cell Renal Cell Carcinoma.

Clear cell renal cell carcinoma (ccRCC) is a prevalent malignant tumor of the urinary system. While tyrosine kinase inhibitors (TKIs) are currently the first-line treatments for advanced/metastatic ccRCC, patients often develop resistance after TKI therapy. Lipid metabolic reprogramming, a hallmark of tumor progression, contributes to acquired drug resistance in various malignant tumors.

Long-term follow-up of thumb reconstruction with a heterotopic replanted finger: case report and literature review.

Objectives: This work aimed to study the long-term outcome and function of a heterotopic replanted finger.

Methods: Retrospective analysis of two cases of successful finger reconstruction after finger heterotopic replantation. One case was a severed thumb, and the other case was a severed finger.

SPINK13 acts as a tumor suppressor in hepatocellular carcinoma by inhibiting Akt phosphorylation.

The PI3K/Akt pathway is overexpressed in nearly 50% of hepatocellular carcinomas and inhibits apoptosis by promoting the expression of antiapoptotic genes. Serine protease inhibitors have been shown to induce apoptosis in hepatoma cells by downregulating SPINK13 in the PI3K/Akt pathway. In this study, SPINK13 was expressed in lentiviral vectors.

Combined Analysis of Second- and Third-Generation Transcriptome Sequencing for Gene Characteristics and Identification of Key Splicing Variants in Wound Healing of Ganxi Goat Skin.

Ganxi goat is a local breed of goat unique to Jiangxi Province, China, named for its primary distribution in the Ganxi region. Ganxi goats are primarily raised through grazing, showing good adaptation to the local humid and hot climate, strong disease resistance, and occupying an important position in the local livestock industry. The skin, as the main barrier of the body, plays an indispensable role in resisting the invasion of external pathogenic factors and has received increasing attention in the medical and scientific fields.

Multidimensionally ordered mesoporous intermetallics: Frontier nanoarchitectonics for advanced catalysis.

Ordered intermetallics contribute to a unique class of catalyst materials due to their rich atomic features. Further engineering of ordered intermetallics at a mesoscopic scale is of great importance to expose more active sites and introduce new functions. Recently, multidimensionally ordered mesoporous intermetallic (MOMI) nanoarchitectonics, which subtly integrate atomically ordered intermetallics and mesoscopically ordered mesoporous structures, have held add-in synergies that not only enhance catalytic activity and stability but also optimize catalytic selectivity.

Characteristics of Nocturnal Boundary Layer over a Subtropical Forest: Implications for the Dispersion and Fate of Atmospheric Species.

The nocturnal boundary layer (NBL) significantly influences the dispersion and fate of atmospheric species at night. Subtropical forests are crucial in carbon and water exchange between the biosphere and the atmosphere. However, the NBL characteristics and their impact on atmospheric species over these forests remain unknown.

Global research progress of electroencephalography applications in attention deficit hyperactivity disorder: Bibliometrics and visualized analysis.

Attention deficit hyperactivity disorder (ADHD) is a profound neurodevelopmental disorder. Currently, the diagnosis of ADHD relies on clinical assessments and lacks objective testing. Research in electroencephalography (EEG) offers new hope for the diagnosis of ADHD, with researchers actively seeking objective EEG biomarkers.

Construction of Cyclodextrin-Based Covalent Organic Frameworks for Efficient Encapsulation of Menthol.

The application of flavoring ingredients like menthol in the food industry is hindered by their high volatility and poor thermal stability, which lead to significant losses during processing and storage. Encapsulation of flavors into porous materials to obtain inclusion complexes (ICs) has proved to be an efficient strategy. In the present study, we synthesized a series of relatively food-safe three-dimensional anionic cyclodextrin-based covalent organic frameworks (CD-COFs) with spiroborate linkages using a facile microwave-assisted method.

Photoinduction of Ferroptosis and cGAS-STING Activation by a HS-Responsive Iridium(III) Complex for Cancer-Specific Therapy.

Triggering ferroptosis represents a promising anticancer therapeutic strategy, but the development of a selective ferroptosis inducer for cancer-specific therapy remains a great challenge. Herein, a HS-responsive iridium(III) complex has been well-designed as a ferroptosis inducer. could selectively light up HS-rich cancer cells, primarily localize in mitochondria, intercalate into mitochondrial DNA (mtDNA), and induce mtDNA damage, exhibiting higher anticancer activity under light irradiation.

Safety and feasibility of "Pant-Shaped" anastomosis in laparoscopic-assisted total gastrectomy: Study of 210 cases at a single center.

Background: Advancements in laparoscopic technology have popularized laparoscopic total gastrectomy over traditional open surgery, yet postoperative complications like anastomotic leakage and stenosis persist, particularly in esophagojejunostomy. To address this, since 2017, the authors have introduced the "Pant-Shaped" esophagojejunostomy as an improvement over the classic Roux-en-Y method, especially beneficial for patients with small intestinal diameters or those with gastric body cancer or Siewert III.

Objective: To assess the viability and safety of employing 'Pant-Shaped' anastomosis following laparoscopic-assisted total gastrectomy.

: possible mechanism of infection of goat uterus and its effects on uterine autophagy and cell apoptosis.

Listeriosis is highly prevalent in the animal farming industry, with as the causative pathogen. To identify potential therapeutic targets for LM infection, we investigated the mechanisms of LM infection in goat uteri. We inoculated a group of goats with LM via jugular vein injection, isolated and raised them, and subsequently collected sterile samples of their uterine tissue after they exhibited clinical symptoms of LM infection.

Current status and future prospects of pretreatment for tobacco stalk lignocellulose.

With the growing demand for sustainable development, tobacco stalks, as a resource-rich and low-cost renewable resource, hold the potential for producing high-value chemicals and materials within a circular economy. Due to the complex and unique structure of tobacco stalk biomass, traditional methods are ineffective in its utilization, making the pretreatment of tobacco stalk lignocellulose a crucial step in obtaining high-value products. This paper reviews recent advancements in various pretreatment technologies for tobacco stalk lignocellulosic biomass, including hydrothermal, steam explosion, acid, alkaline, organic solvent, ionic liquid, and deep eutectic solvent pretreatment.

Preliminary Outcomes of Calcaneal Body Lengthening for the Calcaneus Shortening.

For lengthening irregular bones, such as calcaneus, there are few reports in the literature. This study aimed to introduce the treatment strategy and preliminary outcomes for calcaneus shortening using calcaneal body lengthening. From January 2017 to January 2022, calcaneal lengthening was conducted for three patients (two males and one female) who suffered from traumatic calcaneal shortening.

Two-dimensional single-crystalline mesoporous high-entropy oxide nanoplates for efficient electrochemical biomass upgrading.

Mesoporous single crystals have received more attention than ever in catalysis-related applications due to their unique structural functions. Despite great efforts, their progress in engineering crystallinity and composition has been remarkably slower than expected. In this manuscript, a template-free strategy is developed to prepare two-dimensional high-entropy oxide (HEO) nanoplates with single-crystallinity and penetrated mesoporosity, which further ensures precise control over high-entropy compositions and crystalline phases.

Interplay between oral health and lifestyle factors for cancer risk in rural and urban China: a population-based cohort study.

Background: Although poor oral health and several lifestyle factors have been found to be associated with cancer risk, their joint relationship has rarely been studied.

Methods: We prospectively examined the associations of oral health and healthy lifestyle factors with cancer risk among 0.5 million rural and urban residents from the China Kadoorie Biobank (2004-2015).