Efficiency and safety of cannabinoid medical use: an analysis of discussions and observed trends on Instagram.

Background: Cannabis and its derivatives show encouraging therapeutic effects in the treatment of various diseases. However, further studies are needed to better assess their efficacy and safety. A promising base for research in the field of medicine and additional pharmacovigilance is social networks, in which experience and knowledge are exchanged between researchers, doctors, and patients, as well as information about the potential risks and benefits of using drugs for medical purposes is disseminated.

Features of the regulation of reparative processes of chronic wounds in response to the effect of photobiomodulation therapy on a wound defect. Photobiomodulation therapy for chronic wounds.

Background: One of the promising methods of influencing the wound process is photobiomodulation (PBM) therapy. The optimal parameters of PBM therapy have not yet been found because the molecular mechanisms of light interaction with tissue are not fully understood.

Objective: Studying the influence of PBM of various parameters on the regulation of reparative process- es of chronic wounds using the example of indicators of aggregation activity of platelets, platelet-derived growth factor (PDGF), interleukin-8 (IL-8), and amino-terminal propeptide of type III procollagen (PIIINP) at the remodeling stage.

Activation of reparative processes of chronic wounds using photobiomodulation therapy (experimental study).

Objective: Aim: The aim of the work was to study the ef f ect of photobiomodulation therapy on the regulation of disorders in the healing of chronic wounds at the remodeling stage using indicators of platelet aggregation activity, reactive oxygen species, platelet-derived growth factor, and interleukin-1β.

Patients And Methods: Materials and Methods: The study included 3 groups of Wistar rats: intact animals and animals of the control and experimental groups, for which chronic wounds were simulated. Rats in the experimental group received photobiomodulation therapy once a day for 5 days.

Digital Technology Applications in the Management of Adverse Drug Reactions: Bibliometric Analysis.

Adverse drug reactions continue to be not only one of the most urgent problems in clinical medicine, but also a social problem. The aim of this study was a bibliometric analysis of the use of digital technologies to prevent adverse drug reactions and an overview of their main applications to improve the safety of pharmacotherapy. The search was conducted using the Web of Science database for the period 1991-2023.

Patient safety discourse in a pandemic: a Twitter hashtag analysis study on #PatientSafety.

Background: The digitalization of medicine is becoming a transformative force in modern healthcare systems. This study aims to investigate discussions regarding patient safety, as well as summarize perceived approaches to mitigating risks of adverse events expressed through the #PatientSafety Twitter hashtag during the COVID-19 pandemic.

Methods: This research is grounded in the analysis of data extracted from Twitter under the hashtag #PatientSafety between December 1, 2019 and February 1, 2023.

Patent and Bibliometric Analysis of the Scientific Landscape of the Use of Pulse Oximeters and Their Prospects in the Field of Digital Medicine.

This study conducted a comprehensive patent and bibliometric analysis to elucidate the evolving scientific landscape surrounding the development and application of pulse oximeters, including in the field of digital medicine. Utilizing data from the Lens database for the period of 2000-2023, we identified the United States, China, the Republic of Korea, Japan, Canada, Australia, Taiwan, and the United Kingdom as the predominant countries in patent issuance for pulse oximeter technology. Our bibliometric analysis revealed a consistent temporal trend in both the volume of publications and citations, underscoring the growing importance of pulse oximeters in digitally-enabled medical practice.

Patent analysis of digital sensors for continuous glucose monitoring.

The high need for optimal diabetes management among an ever-increasing number of patients dictates the development and implementation of new digital sensors for continuous glucose monitoring. The purpose of this work is to systematize the global patenting trends of digital sensors for continuous glucose monitoring and analyze their effectiveness in controlling the treatment of diabetes patients of different ages and risk groups. The Lens database was used to build the patent landscape of sensors for continuous glucose monitoring.

Patent landscape review of non-invasive medical sensors for continuous monitoring of blood pressure and their validation in critical care practice.

Objectives: Continuous non-invasive monitoring of blood pressure is one of the main factors in ensuring the safety of the patient's condition in anesthesiology, intensive care, surgery, and other areas of medicine. The purpose of this work was to analyze the current patent situation and identify directions and trends in the application of non-invasive medical sensors for continuous blood pressure monitoring, with a focus on clinical experience in critical care and validation thereof.

Materials And Methods: The research results reflect data collected up to September 30, 2022.

Bibliometric analysis and evidence of clinical efficacy and safety of digital pills.

Digital pills are new technologies that aim to improve healthcare by increasing medication adherence. The aim of the work was a bibliometric analysis of clinical studies of digital pills and an assessment of the level of evidence of their effectiveness, safety, and prospects for the future. The studies were conducted using online databases such as ClinicalTrials.

Digital Pills with Ingestible Sensors: Patent Landscape Analysis.

The modern healthcare system is directly related to the development of digital health tools and solutions. Pills with digital sensors represent a highly innovative class of new pharmaceuticals. The aim of this work was to analyze the patent landscape and to systematize the main trends in patent protection of digital pills with ingestible sensors worldwide; accordingly, to identify the patenting leaders as well as the main prevailing areas of therapy for patent protection, and the future perspectives in the field.

Features of cellular and molecular mechanisms of re-gulation of reparative processes in chronic wounds using photobiomodulation therapy.

Treatment of chronic wounds is an urgent worldwide problem for medicine. Among the many efforts in wound healing techniques, photobiomodulation therapy has shown promising results.

The influence of foreign textile bodies from military clothes on the healing process of experimental injuries of soft tissues.

Background: The healing of combat wounds can be complicated by the presence of foreign bodies, including fragments of military clothing. The present work aims to study the morphological features of soft tissue injuries with textile fibers implanted into wounds, personnel military forms during wound healing, in the experiment.

Methods: By randomization, 54 rats were divided into 3 groups.

THE ABILITY OF YOUNG PEOPLE TO SELF-REGULATE EMOTIONS AS MENTAL HEALTH SIGN.

Objective: The aim: To determine the differences in the ability of young people with low and high economic statuses towards emotional self-regulation, and characterize their frame of mind by analyzing functional and dysfunctional emotions in healthy and unhealthy states.

Patients And Methods: Materials and methods: Theoretical - analysis, generalization, interpretation of the collected data; a set of empirical methods - "Attitude to health" by Berezovskaya, the scale "Quality of life" in the adaptation by Vodopyanova, self-assessment income scale and validated questionnaire "Subjective economic well-being" by Khashchenko. The author has applied Pearson's chi-squared test, Student's t-test, and Kruskal-Wallis test.

Descriptive characteristics of occupational exposures and medical follow-up in the cohort of workers of the Siberian Group of Chemical Enterprises in Seversk, Russia.

Purpose: To date, only a few studies have examined long-term health risks of exposures in the uranium processing industry and reported contradictory results, necessitating further research in this area. This is the first description of a cohort of ∼65,000 uranium processing workers (20.6% women) of the Siberian Group of Chemical Enterprises (SGCE) in Seversk, Russia, first employed during 1950-2010.

Healing features of experimental injuries of soft tissues that contain foreign bodies in the form of fragments of military personnel uniforms.

Introduction: The healing of combat wounds can be complicated by the presence of foreign bodies. The present research aimed to study the regeneration of soft tissue injuries complicated by foreign bodies in the form of fragments of military uniforms.

Methods: 60 rats were divided into four groups: intact (Int), control (Con) and two experimental (EG1, EG2).

[Pathological redundancy of the motor act: modern concepts of the pathogenesis and approaches to the pharmacological treatment].

The authors present characteristics of pathogenetic mechanisms of pathological motor redundancy in children with neurological and psychoneurological pathologies examined in accordance with the original author's concept. Pathological mechanisms of the development of motor redundancy, including obsessive movements, hyperkinesia, compulsions, motor and sensory stereotypes, taking into account a certain unity of mechanisms of their origin at the anatomical level, are described. The article demonstrates the differences in the formation of these pathological motor acts associated with changes in their function, i.

DIAGNOSTIC CRITERIA AND ASSESSMENT OF THE FUNCTIONAL CONDITION OF THE COLON IN PATIENTS WITH CHRONIC CONSTIPATION.

The Purpose Of The Study: To determine methods of functional diagnostics of disorders of motor-evacuation properties of the colon, to study motor activity with involvement in the pathological process of certain segments.

Materials And Methods: The basis of our work comes from the experience of a survey of 389 patients with chronic constipation for congenital anomalies of the colon. On the basis of the results proposed to be chronic constipation.

BONE REGULATORY MECHANISMS DESTRUCTION IN EXPERIMENTAL CHRONIC KIDNEY DISEASE.

The aim of our study was to investigate the role of intercellular mediators – interleukin-1 receptor antagonist (IL-1 RA), interleukin-17 (IL-17), receptor activator of nuclear factor kB ligand (RANKL) and osteoprotegerin in the mechanisms of metabolic regulation of renal and bone tissue on model of violations of bone remodeling in chronic kidney disease (CKD). It was found a significant increase in the content of cytokines IL-1 RA (4,207 ± 0,546 pg/ml), IL-17 (33,944 ± 0,938 pg/ ml), osteoprotegerin (28,338 ± 1,223 pg/ml) and RANKL (0,184 ± 0,018 pmol/l) in the serum of animals in violation of bone remodeling in CKD compared with the contents of the studied cytokines in animals in the control group (2,529 ± 0,132 pg/ml, 28,166 ± 0,526 pg/ml, 21,588 ± 0,763 pg/ml and 0,131 ± 0,006 pmol/l, respectively) (P<0.05).

Targeting gene expression to the female larval fat body of transgenic Aedes aegypti mosquitoes.

As the fat body is a critical tissue for mosquito development, metamorphosis, immune and reproductive system function, the characterization of regulatory modules targeting gene expression to the female mosquito fat body at distinct life stages is much needed for multiple, varied strategies for controlling vector-borne diseases such as dengue and malaria. The hexameric storage protein, Hexamerin-1.2, of the mosquito Aedes atropalpus is female-specific and uniquely expressed in the fat body of fourth instar larvae and young adults.

[Contamination of imported and native food products by toxic elements (comparative aspect)].

Analyzed data from monitoring chemical contamination by toxic elements of imported and native food products.

[Evaluation of the results of monitoring food safety in Russia. Mycotoxins].

In this report have been accounted analysis of the results monitoring of food's contamination by mycotoxins as argument of possible to observe food's contamination on links by food chain.

[Elaboration of method for monitoring of food chemical contamination in real time].

There are presented method approach to analysis of the monitoring results of food chemical safety in real time; offered the model of present and research of montoring results for reveal of importanceb pollutions.

Functional and structural characterization of DR_0079 from Deinococcus radiodurans, a novel Nudix hydrolase with a preference for cytosine (deoxy)ribonucleoside 5'-Di- and triphosphates.

The genome of the extremely radiation resistant bacterium Deinococcus radiodurans encodes 21 Nudix hydrolases, of which only two have been characterized in detail. Here we report the activity and crystal structure for DR_0079, the first Nudix hydrolase observed to have a marked preference for cytosine ribonucleoside 5'-diphosphate (CDP) and cytosine ribonucleoside 5'-triphosphate (CTP). After CDP and CTP, the next most preferred substrates for DR_0079, with a relative activity of <50%, were the corresponding deoxyribose nucleotides, dCDP and dCTP.