The first-in-human implantation of the CorNeat keratoprosthesis.

Objectives: To describe the first clinical implantation of the CorNeat™ keratoprosthesis, which utilizes a polymeric scaffold for biointegration within ocular tissue.

Methods: The CorNeat keratoprosthesis was implanted in the right eye of a patient with bilateral corneal opacification and neovascularization secondary to multiple failed grafts. The following surgical technique was used: 360 degree peritomy; epithelial scraping and corneal marking; pre-placement of three corneo-scleral sutures through the implant; central trephination using a 7 mm trephine and host cornea removal; keratoprosthesis placement and sutures tightening while fitting the corneal edge into the posterior groove of the CorNeat keratoprosthesis; and repositioning of the conjunctiva over the implant skirt and fixation with sutures and Fibrin sealant.

Remote Surgeon Virtual Presence: A Novel Telementoring Method for Live Surgical Training.

Purpose: We describe the first known use of telementoring in corneal surgery and technology combining a 3-dimensional microscope system, 5G live streaming technology, group chat software, and a virtual reality headset for intercontinental surgical supervision.

Methods: Three surgeons in Toronto were proctored by a surgeon in Israel in the implantation of a novel keratoprosthesis device (CorNeat KPro; Ra'anana, Israel) into cadaver eyes. In Toronto, the NGENUITY platform (Alcon) transmitted high-definition, 3-dimensional images to the proctor in Israel who viewed the live video through a GOOVIS Virtual Reality headset with subsecond latency.

CorNeat KPro: Ocular Implantation Study in Rabbits.

Purpose: The purpose of this study was to evaluate surgical feasibility and long-term integration of the CorNeat Keratoprosthesis (KPro), a novel synthetic cornea, in rabbits.

Methods: The CorNeat KPro is a synthetic corneal implant designed to treat corneal blindness by using a polymeric scaffold for biointegration, consequently assimilating synthetic optics within ocular tissues. Eight New Zealand White rabbits were implanted unilaterally with the CorNeat KPro and observed for 6 months.

Penetration of moxifloxacin through crosslinked corneas.

Purpose: To determine the ability of moxifloxacin to penetrate the rabbit eye after corneal collagen crosslinking (CXL) with riboflavin and ultraviolet-A light irradiation.

Setting: Harlan Biotech Israel, Rehovot, Israel.

Design: Experimental study.

Treatment of dry eye syndrome with orally administered CF101: data from a phase 2 clinical trial.

Objective: To explore the safety and efficacy of CF101, an A(3) adenosine receptor agonist, in patients with moderate to severe dry eye syndrome.

Design: Phase 2, multicenter, randomized, double-masked, placebo-controlled, parallel-group study.

Participants: Sixty-eight patients completed the study, 35 patients in the placebo group and 33 patients in the CF101 group.

[The pharmacokinetics of fluorescein, hematoporphyrin and its derivative during the development of granuloma].

In experiments on rats with granuloma reproduced by subcutaneous implantation of foreign material there was shown a slowing of excretion from the organism as well as a considerable redistribution between the organs of fluorescein, hematoporphyrin and its derivative as compared with intact animals. The noted changes practically did not depend on the time of granuloma development.

[Use of carbon dioxide laser in emergency surgery of the extrahepatic bile ducts].

The principles of surgical techniques of operations with the use of carbon dioxide laser were developed on basis of the authors' personal experience of 8 years in surgical interventions on 65 patients. The stages of the operative approach, cholecystectomy, choledochotomy, +choledocho-duodeno-anastomosis, papillosphincterotomy, and sterilization of the operative wound and intraabdominal abscesses are illustrated by professionally drawn illustration-diagrams. Laser separation of the gallbladder from the liver takes 220 +/- 35 sec, laser hemostasis and cholestasis of the gallbladder bed--245 +/- 40 sec, laser choledochotomy--17 +/- 8 sec, laser duodenotomy--33 +/- 9 sec.

[Treatment of suppurative diseases of soft tissues by CO2 laser and immobilized trypsin].

The results of treatment of 245 patients with purulent diseases of the soft tissues are discussed. The course of the wound process was most favourable with the use of immobilized trypsin on gauze in the management of wounds formed after surgical debridement of purulent foci by means of CO2 laser. The method made it possible to accelerate the processes of necrolysis, provide a stable low level of dissemination of bacteria in the wound tissues, reduce the term of preparation of the wound for the application of secondary sutures and the terms of healing.

[Use of CO2 laser for surgical debridement of wounds].

The article deals with the results of experimental research in determining the optimum parameters of laser radiation for surgical debridement of wounds and the techniques of its performance. It presents the results of treatment of 137 patients with incised wounds of various localization with the use of a carbon dioxide laser beam. Sterility of the wound surface was produced in 96-97% of cases after wound debridement with a laser beam; uncomplicated healing of wounds was noted in 90% of cases.

[A method of laser seromyotomy of the stomach].

A technique of laser seromyotomy was developed as a method for vagus denervation for the treatment of gastroduodenal ulcers. Soviet Raduga neodymium YAG laser and foreign Medilaz and Flexilas units were employed as sources of laser irradiation. The operation was performed in the 'contact scalpel' mode with the use of Soviet sapphire tips.

Operative angiography by intraarterial digital subtraction angiography: a new technique for quality control of carotid endarterectomy.

Fifty patients who had carotid bifurcation endarterectomy as their sole surgical procedure underwent intraoperative completion angiography by means of portable intraarterial digital subtraction angiography. All had subsequent intravenous digital subtraction angiography or duplex scanning during early follow-up. After the endarterectomy site was closed and before the wound was closed, 6 to 8 ml of contrast was injected through a 21-gauge needle while fluoroscopy was performed with a conventional C-arm.

[Use of infrared ray laser irradiation in the rehabilitation treatment of patients with long-term crush syndrome in an emergency care hospital].

The principle 'rehabilitation starts in a resuscitation ward' has been realized in the resuscitation treatment of 34 patients with the prolonged crush syndrome (PCS) who were injured during the earthquake in Armenia. Laser therapy has been fairly effective, normalizing the external respiration function and central hemodynamics and reducing the blood coagulability. Instrumental vibration massage and acupuncture are recommended to be added to rehabilitation treatment of PCS patients.

[Use of carbon dioxide laser radiation in the treatment of wounds in children].

Results of treatment of 84 children with purulent and posttraumatic wounds with the help of CO2 laser are analyzed. The laser was used as a "surgical scalpel" and for necrectomy in suppurations. The focused and disfocused laser rays were used.