[Experience of ribomunyl application in patients with chronic bronchitis].

The authors performed clinical and immunological evaluation of efficacy of treatment of patients with occupational chronic bronchitis (CB) working in contact with pneumotropic pollutants, including airway irritants and dusts. The complex therapy included an immune-correcting agent of bacterial origin, ribomunyl. The indicators to the drug administration were remission or moderate manifestations of the disease with disturbances of mucosal immunity, both isolated (imbalance of IgA, IgG and salivary lysozyme) or combined with systemic immunity disorder (decrease of neutrophilic phagocyte activity, serum IgM and IgG, and the number of T-lymphocytes).

[Bronchial and pulmonary diseases in workers exposed to irritant gases].

Individuals working in atmosphere of relatively medium (up to 3 MACs) levels of irritant gases demonstrate 1.7 times higher incidence of chronic bronchitis vs. general population does.

[Specific features of adverse effects in workers exposed to different levels of methylmethacrylate].

The relation of the incidence of malignant neoplasms to the dose of methyl methacrylate (MMA) was studied in 3588 workers. There was a clear correlation between the dose of MMA and the risk for cancer of the genital system in females and of the lung in males. Examining the immunity in groups receiving different doses of MMA revealed significant immunological disorders when exposed to its high concentrations.

[Pathogenesis of tolylene diisocyanate intoxication].

Experimental and clinical investigations to evaluate immunity, lipid peroxidation (LPO), and antioxidative defense (AOD) under the action of tolylene diisocyanate at the level of MAC and 10 MAC were conducted for further studies of the agent's pathogenetic mechanisms. The experimental investigations showed the predominant activation of cellular and humoral immunities, as well as the suppression of nonspecific defence at 10 MAC, enhanced LPO, and phasic changes in AOD. Most profound immunological changes were observed in those having as long as 5 years of length of service.

[The immune system status among those working under the influence of biological, chemical and physical factors].

The authors compared main immune parameters in workers contacting various occupational hazards. The studies revealed that actual hazards induced variable associations of disorders in cellular, humoral immunity, nonspecific protective factors, local immunity of saliva and allergic reactivity.

[The immune system status after the impact from local vibrations].

The article presents results of immunologic studies in 111 vibration disease sufferers with variable exposure, age, sex and severity of disease. The examinees were proved to have depressed cellular immunity--lower E-RFC count with decreased number of active E-RFC and levamisole--correctable modifications of T-cells; inhibited humoral immunity--lower levels of IgM, IgG, IgA; contradictory changes of neutrophils functions--depressed phagocytosis and metabolic activity with pronounced rosette formation; halted immune factors of saliva.

[Immune status of workers at a hydrolysis yeast plant].

The clinical and immunologic study involving a complex of immunologic parameters covered 52 workers of yeasting hydrolysis production. The results are--depression of cellular immunity with modified T-cellular membranes; inhibited phagocytic activity of neutrophils and increased expression of E-receptors; disbalanced saliva immune factors; sensibilization to fungus producing hydrolysis yeast. The study revealed immune features varying with degree of exposure to the occupational materials, with length of service and health state of the examinees.

[State of local immunity under exposure to anthropogenic factors of biological, chemical and physical nature in industry].

The authors studied immunologic features of saliva in 1714 workers exposed to vibration and other occupational hazards in microbiologic, chemical enterprises. The examinees demonstrated lower activity of lysozyme and concentrations of IgA, higher levels of IgG. Immunologic features of saliva was proved to have extreme diagnostic importance, therefore could be used to detect early signs of exposure to occupational hazards and to diagnose pathologic conditions caused by those hazards.

[Selection of diagnostically significant parameters in integral evaluation of the effects of occupational biologic and chemical hazards].

Clinical and immunologic study including evaluation of immune state, allergic reactivity and adaptation covered 1174 workers engaged into microbiologic synthesis of proteins (production of proteovitamin concentrates and hydrolytic yeast) and 543 ones working at chemical enterprises in contact with gases irritating respiratory tract, with isocyanate and acryl compounds. Homeostasis of the examinees was assessed by means of an integral parameter, and the parameter's limits were defined for the diseases under study. The research determined diagnostically valuable parameters for some entities diagnosed in the examinees.

[Information content of immunologic parameters in the evaluation of the effects of hazardous substances].

Clinical and immunologic examination including 1 and 2 level tests covered 429 staffers of chemical enterprises and 1122 of those engaged into microbiological synthesis of proteins, both the groups exposed to some irritating gases and isocyanates. Using calculation of Kulbak's criterion, the studies selected informative parameters to diagnose immune disturbances caused by occupational hazards. For integral evaluation of immune state, the authors applied general immunologic parameter, meanings of which can serve as criteria for early diagnosis of various immune disorders and for definition of risk groups among industrial workers exposed to occupational biologic and chemical hazards.

[Allergic effects on the population of industrial air pollutants].

Increasing of the allergization of the population in industrial regions caused by chemical pollution of the air was noted. Some changes in respiratory tract and blood count were reported also.

[Comparative evaluation of efficiency of various immunologic reactions with Candida antigens in detecting immediate hypersensitivity].

In the dynamic survey of 577 persons having had contacts with yeast-like fungi of the genus Candida the effectiveness of tests for the diagnosis of mycogenic sensitization was made with the use of a number of immunological methods. The basophil degranulation test was shown to have higher sensitivity and specificity in the detection of hypersensitivity to microbial strains used in the production processes of microbiological synthesis, while the use of polysaccharide antigens is more expedient in immunological reactions, such as the precipitation test with the finished product obtained by these processes and with C. albicans.

[The dynamic immunological indices in in vivo stimulation with a Candida antigen].

The results of the study of some immunity characteristics in patients with broncho-pulmonary diseases of allergic etiology, appearing under the influence of yeast-like fungi of the genus Candida, before the intradermal injection of Candida antigen and 24 and 48 hours after such injection are presented. A decrease in the content of peripheral blood lymphocytes, in the levels of T- and B-cells, changes in the frequency and intensity of immediate and delayed hypersensitivity reactions under the influence of antigenic stimulation have been established.

[Professional diseases caused by the action of antibiotics].

A follow-up study is presented of the clinical aspects and pathogenesis of professional diseases due to the effect of antibiotics. A progressing, stable and regressing course of the disease was singled out. It is shown that in the long-term period the main pathogenetic mechanism was allergic vasculitis caused by penicillin, streptomycin and Candida fungi.

[Medico-biological criteria of the evaluation of air quality at the site of microbiological synthesis plants].

The efficacy of environmental protection in the areas of location of protein synthesis microbiologic plants was analyzed. It was established that under the conditions of observance of a technological regime and the stability of the gas cleaning systems for industrial affluents the operation of the plants caused no air pollution of residential districts by fungi producers and protein dust of the finished product. The study revealed the absence of detrimental health effect of microbiologic products.

[Use of immunomycologic indicators in solving the problems of health protection of pregnant workers in the microbial synthesis industry].

The study of 106 pregnant women engaged in microbiological synthesis production revealed the tendency to increasing genitalia contamination by Candida yeast-like fungi, including fungi-protein producers, and also oppression of immunologic reactivity in comparison with nonpregnant women and the control group. It was pointed out that from the beginning of their pregnancy period women should have no contact with yeast-like fungi.

[Nature of the human immune response to exposure to protein-producing microorganisms].

The influence of the live culture and dried biomass of yeast-like fungi of the genus Candida on the characteristics of immune response in 1094 persons exposed to different concentrations of these fungi was studied. The subjects developed sensitization, manifested by immediate and cellular hypersensitivity reactions, as well as by disturbances in T-dependent and humoral immunity. The pattern of the detected changes depended on the concentration of the active factors and on the systemic condition of the subjects.