Flexibility, Photothermal Property, Antibacterial Ability, and Mineralization Activity of Cu/Mn-Doped Inorganic Nanofibers.

Inorganic nanofibers have emerged as a promising frontier in biomedical research thanks to their unique nanomorphology and bioactivity. Furthermore, the ions released from these inorganic biomaterials play a crucial role in determining cell identity and driving tissue-specific functions. Notably, Cu and Mn, which are essential trace elements in the human body, play significant roles in promoting bone health and participating in metabolic processes.

Multifunctional 3D matrixes based on flexible bioglass nanofibers for potential application in postoperative therapy of osteosarcoma.

Postoperative treatment of osteosarcoma is one of the major challenging clinical issues since both elimination of residual tumors and acceleration of bone regeneration should be considered. Photothermal therapy has been widely studied due to its advantages of small side-effect, low-toxicity, high local selectivity and noninversion, and bone tissue engineering is an inevitable trend in postoperative treatment of osteosarcoma. In this study, we combined the tissue engineering and photothermal therapy together, and developed a kind of multifunctional nanofibrous 3D matrixes for postoperative treatment of osteosarcoma.