Systemic therapy timing and use in patients with advanced melanoma at the end of life: A retrospective cohort study.

Novel systemic therapies for advanced melanoma improve survival, but carry potential serious side effects and high costs. This study aimed to assess the timing and use of systemic therapies in the months before death. Patients diagnosed with advanced melanoma (July 2017-June 2020) who died before July 2020 were selected from the Netherlands Cancer Registry.

A novel concept for the control of Aujeszky's disease: experiences in two vaccinated pig herds.

A study was conducted to examine the usefulness of a glycoprotein I (gI)-ELISA to monitor Aujeszky's disease virus infection in two vaccinated pig herds; the gI-ELISA can differentiate between pigs infected with Aujeszky's disease virus and pigs vaccinated against Aujeszky's disease with gI-negative vaccines. The two herds had been vaccinated with gI-negative vaccines for several years. The first survey, in September 1986, revealed that approximately 10 per cent of the breeding pigs in a large multiplier herd were seropositive for antibodies to gI of Aujeszky's disease virus, and it was decided to try to eliminate the virus from the herd by gI-ELISA testing and culling of gI-seropositive pigs.

A longitudinal study of starvation in piglets and the introduction of a modified liver biopsy technique.

The effect of starvation on blood glucose, muscle glycogen and liver glycogen concentration was measured in a group of newborn piglets. Liver biopsies were obtained by using a modified version of the Menghini technique. No difference in length of survival time was observed between piglets that received water and those that did not.

Comparison of blood glucose concentrations measured by enzymatic and reflectance photometric methods in fasting piglets.

During a metabolic study of 22 fasting newborn piglets, blood glucose concentrations were measured by enzymatic and reflectance photometric methods. Use of the reflectance photometer is an accurate method of determining blood glucose levels even in hypoglycaemic range. In addition, the minimal quantity of blood needed for measurement allows the use of the same newborn piglets in longitudinal studies in which samples must be taken frequently.

Comparative pharmacokinetics and bioavailability of eight parenteral oxytetracycline-10% formulations in dairy cows.

In plasma and milk the oxytetracycline (OTC) concentrations were determined following a single intramuscular administration of eight 10%-formulations to dairy cows at a dose of approximately 5 mg/kg. Two of these formulations were injected intravenously to obtain reference values of the drug's pharmacokinetic parameters. The eight formulations were compared and evaluated pharmacokinetically with respect to absorption rate, peak plasma and milk OTC concentrations, biological half-life, and relative bioavailability.

Pharmacokinetics and renal clearance of oxytetracycline after intravenous and intramuscular administration to dairy cows.

Following intravenous administration of an oxytetracycline-HC1 and an oxytetracycline-dihydrate formulation to dairy cows, no statistical difference could be found between the pharmacokinetic parameters, derived from the three-compartment model, of these preparations. Urinary recovery was continued for a period of 72 h following intravenous or intramuscular OTC administration. The recovery of OTC in the urine in the 72-h period was in the range of 73% to 96% of the available dose administered.