Publications by authors named "Lital Mordechay"
Mechanical Regulation of the Cytotoxic Activity of Natural Killer Cells.
ACS Biomater Sci Eng
January 2021
Article Synopsis
- The study examines how natural killer (NK) cells sense mechanical changes in their environment, specifically the stiffness of the surfaces they interact with during activation.
- Researchers discovered that NK cells show a bell-shaped immune response to stiffness, with optimal activation occurring at a specific range of stiffness (hundreds of kPa).
- The findings suggest that not all NK cells respond uniformly to stiffness; a small group increases in size and activity, enhancing the overall immune response, and the clustering of a key protein (DAP10) mirrors this stiffness dependence.