Publications by authors named "Lital Hagai"
Article Synopsis
- A brief hypercapnic challenge during non-invasive BOLD-MRI imaging can detect acute placental hypoperfusion and reveal fetal brain sparing effects, proposing a new method to differentiate between normal and compromised pregnancies.
- Eighteen pregnant ICR mice were tested under different oxygen conditions, and BOLD-MRI showed a significant reduction in signal for various organs in normoxic mice during hypercapnia, indicating impaired placental function.
- The study found that both early- and late-onset hypoxia led to decreased growth and increased fetal neuroapoptosis, particularly in early-onset cases, highlighting the potential of BOLD-MRI to assess chronic fetal health issues related to placental insufficiency.
Article Synopsis
- The study focused on how acute hypercapnia (elevated CO2 levels) affects placental and fetal blood flow in rodents using BOLD-MRI and Doppler ultrasound technologies.
- Findings showed significant reductions in blood flow signals in the placenta, fetal liver, and heart, indicating that these organs experienced reduced blood supply, while the fetal brain showed only minor changes (brain sparing effect).
- Additionally, Doppler ultrasound results indicated heightened umbilical artery pulsatility and decreased fetal heart rate, suggesting signs of acute fetal asphyxia during maternal hypercapnia.*
