Publications by authors named "Lissa Denewet"
Article Synopsis
- Temporal lobe epilepsy (TLE) leads to severe seizures and cognitive dysfunction, particularly affecting spatial memory in patients and animal models.
- The Morris water maze test, commonly used to assess spatial learning in rodents, has limitations like stress and swimming issues, which may skew results, especially in epileptic mice.
- In contrast, the Barnes maze, a dry-land test with milder stressors, shows that epileptic mice can learn the task but struggle to utilize efficient search strategies, suggesting it might be a more effective assessment tool for memory in TLE models.
