[Effect of preoperative chemotherapy, mediastinal lymph node dissection and stump cover on bronchial regeneration following experimental pneumonectomy].

The dynamics of morphological changes occurring in the bronchial stump depending on the extent of mediastinal lymph dissection, preoperative chemotherapy and the stump cover method are discussed. Stump healing after right-side pneumonectomy was assessed in 32 non-inbred dogs. Typical procedure was tested in group 1 while complete systematic mediastinal lymph dissection (CSMLD)--in groups 2-4.

[Retrospective diagnosis of radiation inhalation lesions of the bronchial mucosa in clean-up personnel after the nuclear accident at the Chernobyl nuclear reactor using the micronucleus test].

The aim of the study was to detect radiation lesions in histological samples of bronchial mucosa in Chernobyl wreckers suffering from chronic non-obstructive bronchitis 10 years after Chernobyl accident by the micronuclear test. The study group consisting of Chernobyl wreckers was comparable to the controls by sex, age, smoking and morphological variants of chronic bronchitis. The test in the study group was positive as it showed a significant increase in the number of the ciliated cells in bronchial mucosa as compared to the control group.

[Bacterial infectious process in patients with chronic obliterating bronchiolitis].

Chronic obliterating bronchiolitis in children is characterized by the presence of chronic multifactor inflammatory infectious process with Streptococcus pneumoniae and Haemophilus influenzae being the leading causative agents. The inflammatory process is induced and maintained by S. pneumoniae and H.

[Some aspects of pathogenesis, clinical manifestations and diagnosis of occupational chronic occupational bronchitis].

The article represents data characterizing course of chronic bronchitis in 78 machinery workers subjected to toxic irritative and sensibilizing aerosols. Findings are early bronchial obstruction and pulmonary emphysema, frequent disorders of microcirculation and lesser circle perfusion, propensity to interstitial pulmonary fibrosis and lung hypertension. The results could serve as a base for pathogenetic therapy and necessitate to include COLD into Occupational Diseases Register.

[Prognostic factors influencing results of the surgical treatment of pancreatic cancer].

In patients with carcinoma of the pancreas 128 gastropancreatoduodenal resections (GPDR), 15 distal resections of the pancreas and 3 pancreatectomies were performed. After GPDR 5-year survival was 12%, the survival median was 24.3 months.

[Structural-metabolic features of uremic gastroenteropathy].

Concentrations of uremic toxins in the blood and jejunal juice of 72 patients with chronic renal failure (CRF) were studied as well as morphologic changes in biopsies from jejunal mucosa and submucosa, activity and location of acid and alkaline phosphatase as markers of intracellular and transmembrane transport. It was found that maximal excretion of uremic toxins in the jejunum occurs in CRF stage IIA and IIB. In terminal CRF excretion of uremic toxins delays from their concentration in the blood.

[The ultrastructure of the ciliary epithelium in patients with the Zivert-Kartagener syndrome, bronchiectasis and cystic hypoplasia of the lungs].

Ultrastructure of the cilia of the bronchial epithelium was studied in 26 patients with Zivert-Kartagener syndrome, 12 patients with bronchiectasis and 10 patients with cystic lung hypoplasia. All changes of the cytolemma and cytoskeleton are found to be of a combined type. The degree of the bronchial inflammation was of the decisive influence on the state of the ciliary cells.

[Chronic pancreatitis and cancer of the pancreas].

A microscopic study of 93 preparations of the pancreas from patients with a primary chronic pancreatitis allowed the authors to conclude that the primary chronic pancreatitis is a background favourable for the development of carcinoma, carcinoma of the pancreas being practically always accompanied by an acute inflammatory process. The presence of pancreatitis in patients with carcinoma of the pancreas is responsible for incompetence of pancreatoenteroanastomosis frequently developing in the postoperative period. The application of external controlled trans-anastomosis drainage of the common bile duct and pancreatic ducts resulted in more than 3 times less incidence of this complication.

[Surgical treatment of primary chronic pancreatitis].

Surgical methods of treatment of chronic alcoholic pancreatitis must be chosen with special reference to the state of the duct and parenchyma of the pancreas. Treatment of alcoholic patients should be performed with the participation of psychiatrists.

[Morphologic changes in the adrenal cortex in Itsenko-Cushing's syndrome].

Having studied the results of investigation of 132 patients with Icenko-Cushing syndrome (68 out of them with different structural variants of adrenal tumours, 68--without adrenal tumours), the authors came to the conclusion that adenomas of dark and mixed polymorphic cells belong to hormonally active adrenal tumours, while light-cell monomorphic adenomas belong to hormonally inactive tumours. An electron-microscopic study provides identification of signs of functional activity in adenomas and cancer tumours, to clear up the additional criteria of anaplasia in them. In patients with Icenko-Cushing syndrome, but without a tumour in the adrenal cortex ultrastructural changes in corticocytes are characteristic of the increase of cellular proliferation and the decrease of incretory activity.

[Changes in various biochemical indices and ultrastructure of ascites tumors after combined administration of cyclophosphamide and levorin].

The fractional composition of chromatin proteins and an electron-microscopic pattern of cell ultrastructure of the Ehrlich ascite tumours and ascite lymphoma NK/Ly were studied when suppressing their growth by a combined action of cyclophosphane and polyene antibiotic. Changes in the fractional composition of chromatin proteins were found under the effect of levorin. A sharp increase in this effect and summation of heterogeneous morphological changes provoked by each of the preparation occur under a combined application of the preparations.

[Characteristics of the ultrastructural alteration in ascitic lymphoma NK/Ly cells as affected by cyclophosphane].

The ultrastructure of cells of mouse ascites lymphoma was studied by transmission electron microscopy. It was established that cyclophosphamide treatment (6 days) reduces cell concentration in ascitic fluid and alters tumor cell ultrastructure. Apart from dystrophic and necrotized ones, there are cells exhibiting the signs of active protein synthesis.

[Clinical and morphological comparisons in extravasal stenosis of the celiac trunk].

The results of clinico-morphological examinations of 155 patients (of them 118 operated on) with extravasal stenosis of the celiac trunk due to the squeezing of the celiac plexus by the median arcuate ligament, cruses of the diaphragm, and neurofibrous tissue are presented. All the patients had the symptoms typical of "abdominal angina". The tissues taking part in the squeezing of the celiac trunk: the sympathetic ganglion (27 patients), nerve trunks (66 patients), and the surrounding connective tissue (48 patients) were all characterized by inflammatory and sclerotic alterations.

[Damaging action of lincomycins on the intestines of experimental animals].

It was found that lincomycin and 7-chlor-7-desoxylincomycin administered 3 times induced severe enterocolitis accompanied by dysbacteriosis in a part of the experimental rabbits, while no such phenomenon was observed in the mice. Treatment of the animals with neomycin for 10 days protected them from death of severe forms of enterocolitis.

[Morphological analysis of the Mallory-Weiss syndrome as the basic disease and as a syndrome complicating ischemic heart disease].

On the basis of the analysis of 8 autopsies of Mallory-Weiss syndrome macro- and microscopic changes of the gastric and oesophageal mucosa were found to be similar in Mallory-Weiss syndrome and in the same syndrome accompanying ischemic heart disease. Liver insufficiency and necrobiotic changes of the liver accompanying it are characteristic of Mallory-Weiss syndrome as a distinct disease.

[Characteristics of the action of antibiotics in an experimental process caused by Cl. histolyticum].

The cells of Cl. histolyticum isolated from the muscular tissue of albino mice infected with the microbe and treated with oxyglucocycline or cephaloridin were similar to each other and the cells of the initial strain with respect to their morphological features, growth character on liquid and solid media and saccharolytic activity. The strains isolated from the animals treated with oxyglucocycline were characterized by lower gelatinolytic, hemolytic, caseinolytic and (to a less extent) collogenolytic activity.