Publications by authors named "Lisley Inata Mambelli"
Alphastatin-C a new inhibitor of endothelial cell activation is a pro-arteriogenic agent and retards B16-F10 melanoma growth in a preclinical model.
Adilson Kleber Ferreira Brunella Cristofaro Milene Cristina Menezes Ana Karina de Oliveira Alexandre Keiji Tashima Lisley Inata Mambelli
Oncotarget
December 2020
Most characterized angiogenic modulators are proteolytic fragments of structural plasma and/or matrix components. Herein, we have identified a novel anti-angiogenic peptide generated by the hydrolysis of the C-terminal moiety of the fibrinogen alpha chain, produced by the snake venom metalloprotease bothropasin (SVMP), a hemorrhagic proteinase in Bothrops jararaca venom. The 14-amino acids peptide (alphastatin-C) is a potent antagonist of basic fibroblast growth factor, induced endothelial cell (HUVEC-CS) proliferation, migration and capillary tube formation in matrigel.
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- Cancer cells can potentially transform into a less tumorigenic or normal state, but this process is complicated due to the diversity of cancer cells and their unique genetic and epigenetic factors.* -
- Induced pluripotent stem cells (iPSC) technology has emerged as a promising method for reprogramming cancer cells into a more benign state, offering new avenues for personalized stem cell therapies and drug screening.* -
- The review highlights recent advancements in using iPSC technology for cancer cell reprogramming and its potential to enhance our understanding of cancer initiation and progression.*