Publications by authors named "Lislaine M Klider"

Article Synopsis
  • Apigenin, a flavonoid thought to benefit cardiovascular health, was studied for its effects on vascular function in Spontaneously Hypertensive Rats (SHRs) to understand its mechanisms of action.
  • Vascular beds from SHRs were tested with varying doses of apigenin, showing that its ability to lower blood pressure depended on the presence of endothelial cells and was significantly reduced by inhibitors of nitric oxide and potassium channels.
  • The research concluded that apigenin causes vasodilation primarily through endothelial nitric oxide and calcium-activated potassium channels, suggesting its potential for therapeutic use in cardiovascular diseases and the need for more clinical studies.
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L. is used in Brazilian traditional medicine to treat inflammation, chest pain, and anxiety. This study aimed to investigate the safety and the renal and cardiovascular effects of the volatile oil (VO) and the aqueous (AE) and hydroalcoholic (HE) extracts from .

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Ethnopharmacological Relevance: Croton urucurana Baill. (Euphorbiaceae), popularly known as 'sangue de dragão' is a Brazilian species widely used in traditional medicine for cardiovascular ailments.

Aim: To investigate the cardiovascular effects of the C.

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Ethnopharmacological Relevance: Aloysia polystachya (Griseb) Moldenke (Verbenaceae), popularly known as "burrito", is a South American species widely prescribed by local Brazilian healers for the treatment of cardiovascular diseases. However, its antihypertensive and cardioprotective effects are still unknown.

Aim: To evaluate the role of the ethanol-soluble fraction of A.

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Ethnopharmacological Relevance: Cecropia pachystachya Trécul (Urticaceae) is a medicinal plant popularly known as 'embaúba'. In Brazil, the leaves of this species are used for the treatment of various kidney and cardiovascular diseases. However, there are no detailed studies on the renal and cardiovascular activities of this species.

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Cardiovascular diseases (CVDs) are a group of non-communicable disorders of the heart and blood vessels. Although lifestyle changes as well as pharmacological treatments and surgical interventions are available in many countries, CVDs are still considered the number one cause of mortality worldwide. Hence, considering that most CVDs are caused by genetic and environmental imbalances, micro-RNAs (miRNAs or miRs) appear as a plausible therapeutic option for CVDs as they are able to regulate a wide number of genes due to multiple target sites in different genes.

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Several species of are used medicinally and are reported to have cardioprotective, diuretic, and antihypertensive properties. In Brazil, species are collectively called "sete-sangrias" due to their similar appearances and are also used interchangeably for the same therapeutic purposes. So the aim of the study was to characterize morphoanatomy of leaves and stems, evaluate the safety, and investigate the diuretic, hypotensive, vasodilatory, and antioxidant properties of ethanol-soluble fraction of var (Koehne) S.

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