A Fibrinogen Alpha Fragment Mitigates Chemotherapy-Induced Rearrangements.

Rearrangements in the breakpoint cluster region (bcr) are frequently involved in therapy-induced leukemia, a severe side effect of anti-cancer therapies. Previous work unraveled Endonuclease G as the critical nuclease causing initial breakage in the bcr in response to different types of chemotherapeutic treatment. To identify peptides protecting against therapy-induced leukemia, we screened a hemofiltrate-derived peptide library by use of an enhanced green fluorescent protein (EGFP)-based chromosomal reporter of bcr rearrangements.