Dopaminergic and serotoninergic neurotoxicity of lanthanide phosphate (TbPO) in developing zebrafish.

Rare earth elements (REEs) are exploited for global use in manufacturing. Such activities result in their release into the environment and the transformation into more stable phosphate deposition. The objective of this study was to evaluate molecular and behavioral changes of zebrafish exposed to the synthesized terbium phosphate (TbPO) at concentrations of 10, 20, and 50 mg/L and to determine its potential for neurotoxicity.

Ultrasensitive and Rapid Visual Detection of O157:H7 Based on RAA-CRISPR/Cas12a System.

() O157:H7 is a major foodborne and waterborne pathogen that can threaten human health. Due to its high toxicity at low concentrations, it is crucial to establish a time-saving and highly sensitive in situ detection method. Herein, we developed a rapid, ultrasensitive, and visualized method for detecting O157:H7 based on a combination of Recombinase-Aided Amplification (RAA) and CRISPR/Cas12a technology.

Novel Microbial Palladium Nanoparticles with a High Photothermal Effect for Antibacterial Applications.

Novel biocompatible palladium nanoparticles (Pd-NPs) have been prepared by microorganisms via Y-4. It was demonstrated that ultrasonication treatment of biologically reduced Pd-NPs impart a much higher absorption in NIR regions and a better photothermal conversion efficiency to the material. The as-prepared material showed excellent biocompatibility and antibacterial activity under NIR irradiation.

Nonmonotonic effect of CuO nanoparticles on medium-chain carboxylates production from waste activated sludge.

The growing applications of CuO nanoparticles (NPs) in industrial and agriculture has increased their concentrations in wastewater and subsequently accumulated in waste activated sludge (WAS), raising concerns about their impact on reutilization of WAS, especially on the medium-chain carboxylates (MCCs) production from anaerobic fermentation of WAS. Here we showed that CuO NPs at 10-50 mg/g-TS can significantly inhibit MCCs production, and reactive oxygen species generation was revealed to be the key factor linked to the phenomena. At lower CuO NPs concentrations (0.

Construction of K and Tb Co-doped MnO nanoparticles for enhanced oxidation and detoxication of organic dye waste.

Developing low-cost and efficient materials for dye pollutant removal under mild condition remains a great challenge. Here K and Tb co-doped porous MnO (K-Tb-MnO) nanoparticles with tailored properties including crystal structure, surface area and catalytic activity have been synthesized. Experimental results reveal that K-Tb-MnO nanoparticle has higher specific surface area, Mn content and surface oxygen vacancies than pristine MnO nanoparticle and single-doped MnO materials, showing the uniqueness of dual-doped metal ions.

A TbPO-based capturer for environmental extracellular antibiotic genes by interrogating lanthanide phosphates nanoneedles.

Accurate determination of antibiotic resistance genes (ARGs) in environmental DNA molecules (eDNA) is challenging owing to its low abundance in the aquatic environment. Here we report a facile and cost-efficient approach to extract trace amount of eDNAs in the aquatic environment using LnPO nanomaterials. Among the nanomaterials, less crystalline TbPO nanoneedles was identified as the most prominent candidate for long stranded DNA and short stranded DNA with adsorption efficiency above 97%.

Di(2-ethylhexyl) phthalate induces apoptosis through mitochondrial pathway in GC-2spd cells.

Di(2-ethylhexyl) phthalate (DEHP), a plasticizer of synthetic polymers, is a well-known endocrine disrupting chemical (EDC) and reproductive toxicant. Addressing the unclear mechanism of DEHP-induced reproductive dysfunction, this study used GC-2spd cells to investigate the molecular mechanism involved in the DEHP-induced toxicity in the male reproductive system. The results indicated that the apoptotic cell death was significantly induced by DEHP exposure over 100 μM.

Di-(2-ethylhexyl) phthalate induces apoptosis of GC-2spd cells via TR4/Bcl-2 pathway.

Di-(2-ethylhexyl) phthalate (DEHP) is a widely used environmental endocrine disruptor. Many studies have reported that DEHP exposure causes reproductive toxicity and cells apoptosis. However, the mechanism by which DEHP exposure causes male reproductive toxicity remains unknown.