The influence of dialect loss on tone perception: Diminishing voice quality cues in preserved tone contrast.

This study examines whether cue integration in tone perception undergoes changes caused by disparities in language experience among two groups of multidialectal speakers from Changsha: participants in the dialect-preserving group speak Changsha dialect (CD), Changsha Plastic Mandarin (CPM), and Standard Mandarin (SM), whereas participants in the dialect-lost group speak CPM and SM but not CD. An identification test on T1 and T4 was conducted, both of which are present in the CD and CPM. T1 and T4 are associated with a high pitch, but they differ in pitch height, pitch contour, and voice quality.

Machine learning-enabled mental health risk prediction for youths with stressful life events: A modelling study.

Background: Youths face significant mental health challenges exacerbated by stressful life events, particularly in the context of the COVID-19 pandemic. Immature coping strategies can worsen mental health outcomes.

Methods: This study utilised a two-wave cross-sectional survey design with data collected from Chinese youth aged 14-25 years.

Synthesis and Biological Activities of C1-Substituted Acylhydrazone -Carboline Analogues as Antifungal Candidates.

In our ongoing work to create potential antifungal agents, we synthesized and tested a group of C1-substituted acylhydrazone -carboline analogues - and - for their effectiveness against , , , and . Their compositions were analyzed using different spectral techniques, such as H/C NMR and HRMS, with the structure of being additionally confirmed through X-ray diffraction. The antifungal evaluation showed that, among all the target -carboline analogues, compounds and exhibited more promising and broad-spectrum antifungal activity than the commercial pesticide hymexazol.

Identification of the body fluid donor in mixtures through target mRNA cSNP sequencing.

In forensic practice, mixture stains containing various body fluids are common, presenting challenges for interpretation, particularly in multi-contributor mixtures. Traditional STR profiles face difficulties in such scenarios. Over recent years, RNA has emerged as a promising biomarker for body fluid identification, and mRNA polymorphism has shown excellent performance in identifying body fluid donors in previous studies.

3-Amide-β-carbolines block the cell cycle by targeting CDK2 and DNA in tumor cells potentially as anti-mitotic agents.

β-Carboline alkaloids are natural and synthetic products with outstanding antitumor activity. C substituted and dimerized β-carbolines exert excellent antitumor activity. In the present research, 37 β-carboline derivatives were synthesized and characterized.

Effect of Dexmedetomidine on Postpartum Depression in Women With Prenatal Depression: A Randomized Clinical Trial.

Importance: Postpartum depression (PPD) is emerging as a major public health problem worldwide. Although the particular period and context in which PPD occurs provides an opportunity for preventive interventions, there is still a lack of pharmacologic prevention strategies for PPD.

Objective: To assess the efficacy and safety of dexmedetomidine for prevention of PPD among women with prenatal depression undergoing cesarean delivery.

Folk arts-inspired twice-coagulated configuration-editable tough aerogels enabled by transformable gel precursors.

Aerogels, as famous lightweight and porous nanomaterials, have attracted considerable attention in various emerging fields in recent decades, however, both low density and weak mechanical performance make their configuration-editing capability challenging. Inspired by folk arts, herein we establish a highly efficient twice-coagulated (TC) strategy to fabricate configuration-editable tough aerogels enabled by transformable gel precursors. As a proof of concept, aramid nanofibers (ANFs) and polyvinyl alcohol (PVA) are selected as the main components of aerogel, among which PVA forms a flexible configuration-editing gel network in the first coagulation process, and ANF forms a configuration-locking gel network in the second coagulation process.

Influence of language use on migrant workers' willingness to Urban settlement-based on the CLDS 2016 survey data.

In the framework of China new urbanization construction, migrant workers are of great significance for urban sustainable development. Based on the data of CLDS2016, we used the multi- -ordered Logistics model to effectively explore the influence of migrant workers ' language use on the urban settlement will. The research results showed that the mastery of the urban dialect and the language used after work had a significant impact on the willingness of the migrant workers in the urban settlement, while the language used at work had no significant impact on the migrant workers' willingness to settle in cities.

Smoking cessation and relapse-prevention interventions tailored for expectant and new fathers: protocol of a systematic review and network meta-analysis.

Introduction: Exposure of pregnant women and newborns to secondhand smoke (SHS) can lead to adverse maternal and neonatal health outcomes. Among expectant and new fathers, who are the main source of SHS exposure for pregnant women, new mothers and babies, smoking rates remain high. A partner's pregnancy potentially constitutes a critical period where expectant and new fathers are motivated to quit smoking.

Accuracy of intraoral scanning versus conventional impressions for partial edentulous patients with maxillary defects.

This study aimed to evaluate the accuracy of digital dental impressions obtained by intraoral scanning (IOS) for partial edentulous patients with maxillary defects by comparing them with conventional impression techniques. Ten subjects underwent an experimental procedure where three ceramic blocks were affixed to the healthy palate mucosa. Digital dental impressions were captured using IOS and subsequently imported into software.

Predicting efficacy of sub-anesthetic ketamine/esketamine i.v. dose during course of cesarean section for PPD prevention, utilizing traditional logistic regression and machine learning models.

Objective: Increasing researches supported that intravenous ketamine/esketamine during the perioperative period of cesarean section could prevent postpartum depression(PPD). With the effective rate ranging from 87.2 % to 95.

Is the R&D Expenditure of Listed Companies Green? Evidence from China's A-Share Market.

Whether the company's R&D expenditure has the green attribute is the focus of current environmental economics research. This paper empirically tests the relationship between R&D expenditure and CO emission intensity by taking Chinese A-share listed companies, from 2016 to 2020, as samples. The research found that the R&D expenditure of the company has a significant green effect of reducing its carbon dioxide emission intensity.

Azobenzene/Acid Binary Systems for Colorimetric Humidity Sensing with Reversibility, High Sensitivity, and Tunable Colors.

Humidity sensors are important for humidity detection in many storage and manufacturing processes. Issues like sensibility, response rate, controllability, and material and preparation process costs need to be taken into consideration for practical applications. Herein, we report an investigation on a series of azobenzene/acid binary systems using easily accessible compounds, whose thin films display reversible and widely tunable color changes in response to humidity stimulation, with high sensitivity, fast color change, and recovery speed.

Association between geriatric nutrition risk index and bone mineral density in elderly Chinese people.

Unlabelled: Malnutrition contributes to the occurrence of osteoporosis. This study showed that participants with higher GNRI values had higher levels of BMD. GNRIs were positively correlated with BMD and independently associated with total hip T-score.

Smart supramolecular nanofibers and nanoribbons from uniform amphiphilic azobenzene oligomers.

A series of self-assembled 1D nanostructures, including straight and helix nanofibers, nanoribbons, and nanobelts, were fabricated from uniform amphiphilic azobenzene oligomers with tunable molecular weight and side chain functionality, promoted by multiple and cooperative supramolecular interactions. Additionally, the morphological transformation of the nanofibers was achieved during the photoisomerization process.

Smart azobenzene-containing tubular polymersomes: fabrication and multiple morphological tuning.

A fundamental challenge in nanomaterial science is to facilely fabricate nonspherical polymersomes. Here, several kinds of novel tubular polymersomes were fabricated via self-assembly of amphiphilic azobenzene-containing block copolymers. Besides, their shape could be tuned by multiple approaches including changes in the chemical structure, self-assembly conditions and external stimuli.

Effect of subclinical hyperthyroidism on osteoporosis: A meta-analysis of cohort studies.

Objective: The effect of subclinical hyperthyroidism (SH) on bone mineral density (BMD) remains unclear, as do the linking mechanisms. This review aims to investigate the relationship between SH and bone loss in terms of the gender-dependent effects of SH on BMD.

Methods: The PUBMED, EMBASE, OVID, MEDLINE, SINOMED and COCHRANE LIBRARY databases (inception to August 12, 2019) were searched for cohort studies investigating the effects of SH on BMD.

Microbial osteoporosis: The interplay between the gut microbiota and bones via host metabolism and immunity.

The complex relationship between intestinal microbiota and host is a novel field in recent years. A large number of studies are being conducted on the relationship between intestinal microbiota and bone metabolism. Bone metabolism consisted of bone absorption and formation exists in the whole process of human growth and development.

RNA binding protein PUM2 promotes the stemness of breast cancer cells via competitively binding to neuropilin-1 (NRP-1) mRNA with miR-376a.

Others and ours studies have established the promoting roles of NRP-1 (neuropilin-1) in breast cancer, however, the underlying mechanisms by which NRP-1 is regulated are still confused. Here, bioinformatics analysis indicated that RNA binding protein PUM2 could bind to NRP-1 mRNA. Clinical samples showed that PUM2 expression was significantly increased in breast cancer tissues, negatively correlated with the overall survival and relapse-free survival of breast cancer patients, and positively correlated with NRP-1 expression.

Cooperation of Amphiphilicity and Smectic Order in Regulating the Self-Assembly of Cholesterol-Functionalized Brush-Like Block Copolymers.

Nanoparticle morphology significantly affects the application of nanometer-scale materials. Understanding nanoparticle formation mechanisms and directing morphological control in nanoparticle self-assembly processes have received wide attention. Herein, a series of brush-like amphiphilic liquid crystalline block copolymers, PChEMA - b-POEGMA , containing cholesteryl mesogens with different hydrophobic/hydrophilic block ratios were designed and synthesized.

[Effects of airborne fine particulate matters on pulmonary inflammation injury and Th17/Treg balance of sub-chronic exposure mice].

Objective: To explore effects of fine particulate matters (PM 2.5) onpulmonary inflammation, and the changes of Th17/Treg balance as well as related cytokines.

Method: Thirty-two C57BL/6 male mice were randomly divided into 4 groups including 1 saline control group and 3 PM2.