Publications by authors named "Lisette Mbuyi Kalonji"
Background: Typhoid Fever remains a major cause of morbidity and mortality in low-income settings. The Severe Typhoid in Africa programme was designed to address regional gaps in typhoid burden data and identify populations eligible for interventions using novel typhoid conjugate vaccines.
Methods: A hybrid design, hospital-based prospective surveillance with population-based health-care utilisation surveys, was implemented in six countries in sub-Saharan Africa.
Invasive non-typhoidal (iNTS) (serotypes Typhimurium and Enteritidis) are major causes of bloodstream infections in sub-Saharan Africa, but their reservoir is unknown. Aiming to demonstrate human carriers as a reservoir, we assessed an iNTS disease endemic rural community (Kikonka health area, Democratic Republic of the Congo) for intestinal carriage of iNTS. After a census, healthy subjects from randomly selected households provided three successive stool samples for culture.
View Article and Find Full Text PDFInvasive non-typhoidal Salmonella (iNTS) disease manifesting as bloodstream infection with high mortality is responsible for a huge public health burden in sub-Saharan Africa. Salmonella enterica serovar Typhimurium (S. Typhimurium) is the main cause of iNTS disease in Africa.
View Article and Find Full Text PDFNontyphoidal are a leading cause of community-onset bacteremia and other serious infections in sub-Saharan African countries where large studies indicate that they are an uncommon cause of moderate-to-severe diarrhea. Approximately 535 000 nontyphoidal invasive disease illnesses and 77 500 deaths were estimated to occur in 2017; 422 000 (78.9%) illnesses and 66 500 (85.
View Article and Find Full Text PDFArticle Synopsis
- Azithromycin has been identified as a viable treatment option for invasive non-typhoidal Salmonella (iNTS) infections, and researchers established its epidemiological cut-off (ECOFF) to assess susceptibility.
- The study involved testing various methods of measuring azithromycin susceptibility across 515 iNTS isolates from blood cultures in several countries, using techniques like broth microdilution, agar dilution, and disk diffusion.
- Results showed that the ECOFF for azithromycin was 16 mg/L, and while disk diffusion proved to be an accurate alternative, gradient tests performed better when read at 100% inhibition rather than 80%.
Article Synopsis
- Non-typhoidal Salmonella (NTS) is the leading cause of bloodstream infections in Congolese children under five, with a high fatality rate and associated risk factors such as malaria, anemia, and malnutrition.
- NTS infections peak during the rainy season, suggesting that seasonal changes might influence transmission, prompting researchers to investigate both environmental and host-related factors.
- The study found that rainfall significantly contributes to NTS variations, independent of host factors, emphasizing the need for further environmental studies and public health strategies to address this issue.
Background: Clinical observations and animal studies have suggested that Salmonella intestinal carriage is promoted by concurrent Schistosoma infection. The present study assessed association of Salmonella intestinal carriage and Schistosoma mansoni infection among individuals in a Schistosoma endemic area in sub-Saharan Africa.
Methods: From November 2015 to March 2016, a cross-sectional community-wide study was conducted in Kifua II, a rural village in Kongo Central Province, Democratic Republic of Congo.
Bloodstream infections by Salmonella enterica serovar Typhimurium constitute a major health burden in sub-Saharan Africa (SSA). These invasive non-typhoidal (iNTS) infections are dominated by isolates of the antibiotic resistance-associated sequence type (ST) 313. Here, we report emergence of ST313 sublineage II.
View Article and Find Full Text PDFBackground: This study reports the microbiological landscape of Salmonella Typhi and invasive nontyphoidal Salmonella (iNTS) in the Democratic Republic of the Congo (DRC).
Methods: Blood cultures obtained from hospital-admitted patients suspected of bloodstream infection (BSI) in 4 of 11 provinces in DRC (Kinshasa, Bas-Congo, Equateur, and Orientale) were processed. Sampling had started in 2007; the results for the period 2011-2014 are reported.