Construction and validation of a regulatory T cells-based classification of renal cell carcinoma: an integrated bioinformatic analysis and clinical cohort study.

Purpose: Renal cell carcinoma (RCC), exhibiting remarkable heterogeneity, can be highly infiltrated by regulatory T cells (Tregs). However, the relationship between Treg and the heterogeneity of RCC remains to be explored.

Methods: We acquired single-cell RNA-seq profiles and 537 bulk RNA-seq profiles of TCGA-KIRC cohort.

Erratum: Robust Weak Topological Insulator in the Bismuth Halide Bi_{4}Br_{2}I_{2} [Phys. Rev. Lett. 133, 086602 (2024)].

This corrects the article DOI: 10.1103/PhysRevLett.133.

Skin Effect of Nonlinear Optical Responses in Antiferromagnets.

Nonlinear optics plays important roles in the research of fundamental physics and the applications of high-performance optoelectronic devices. The bulk nonlinear optical responses arise from the uniform light absorption in noncentrosymmetric crystals, and hence are usually considered to be the collective phenomena of all atoms. Here we show, in contrast to this common expectation, the nonlinear optical responses in antiferromagnets can be selectively accumulated near the surfaces, representing a skin effect.

Landau Rainbow Induced by Artificial Gauge Fields.

The ability to generate Landau levels using a pseudomagnetic field (PMF), also called an artificial gauge field, opens up new pathways for exploring fundamental physics and developing novel applications based on topological protection. In this Letter, we simultaneously realize a PMF and a pseudoelectric field (PEF) on a photonic crystal platform and observe a rainbow effect of the Landau zeroth modes. While a PMF induces a series of discretized Landau levels of photons in a similar way as the quantum Hall effect for electrons, a PEF breaks the degeneracy of the flat band of Landau levels over a broad range.

Clinical risk factors of long-term post-traumatic stress symptoms, anxiety, and depression in COVID-19 survivors.

The COVID-19 pandemic has a profound and lasting impact on the mental health of recovered individuals. To investigate the clinical risk factors associated with long-term post-traumatic stress symptoms (PTSS), anxiety, and depression in COVID-19 survivors, demographic information and medical records were collected during February 19 and March 20, 2020. Assessments of PTSS, anxiety, and depressive symptoms were conducted at two months (April to May 2020, Session 1) and two years (April to May 2022, Session 2) post-discharge.

Access to Polyhydroxyalkanoates with Diverse Syndiotacticity via Polymerization by Spiro-Salen Complexes and Insights into the Stereocontrol Mechanism.

Polyhydroxyalkanoates (PHAs) have attracted broad interest as promising sustainable materials to address plastic pollution and resource scarcity. However, the chemical synthesis of stereoregular PHAs via ring-opening polymerization (ROP) has long been an elusive endeavor. In this contribution, we exploited a robust spiro-salen yttrium complex (Y3) as the catalyst to successfully prepare syndiotactic PHAs with diverse pendent groups.

Dynamic Covalent Bonds-Mediated Color-Switchable Circularly Polarized Luminescence in Helical Assemblies of Achiral Liquid Crystal Block Copolymer Films.

Circularly polarized luminescence (CPL) film attracted considerable attention in information storage and encryption, three-dimensional display, and chiral recognition. However, due to the limited molecular mobility within thin film, achieving a high asymmetry factor and non-contact modulation of CPL remain challenging. In this work, color-switchable homochiral CPL films with high luminescence asymmetry factor (glum~0.

A 4D tensor-enhanced multi-dimensional convolutional neural network for accurate prediction of protein-ligand binding affinity.

Protein-ligand interactions are the molecular basis of many important cellular activities, such as gene regulation, cell metabolism, and signal transduction. Protein-ligand binding affinity is a crucial metric of the strength of the interaction between the two, and accurate prediction of its binding affinity is essential for discovering drugs' new uses. So far, although many predictive models based on machine learning and deep learning have been reported, most of the models mainly focus on one-dimensional sequence and two-dimensional structural characteristics of proteins and ligands, but fail to deeply explore the detailed interaction information between proteins and ligand atoms in the binding pocket region of three-dimensional space.

Effects of dichlorobenzene, toluene, benzene and formaldehyde chemicals on Drosophila melanogaster mortality.

Environmental exposures to volatile organic compound (VOC) mixtures have received increasing attention, yet the risks are under studied. This study aimed to explore the risks of combined exposures to several commonly detected VOCs and to draw attention to the necessity of studying long-term and low-concentration environmental exposure patterns. In this study, we examined the effects of long-term and low-concentration exposures to VOCs like 1,2-dichlorobenzene, benzene, toluene and formaldehyde either alone or in combination on D.

Liquid Crystalline Nanorods by Synchronized Polymerization, Self-Assembly and Oriented Attachment for Utilization in Magnetically Responsive Displays.

The creation of anisotropic nanoparticles (NPs) by polymerization and/or self-assembly (SA) has significantly promoted the applications of polymer nanomaterials in many fields. However, polymer nanorods are not easily accessible via conventional polymerization or SA. Here we report a one-step route to synthesize single-domain smectic liquid crystalline (LC) nanorods utilizing oriented attachment (OA) that was usually found in the synthesis of inorganic NPs, synchronized with polymerization and SA.

Current-Regulated Selective Nickel-Catalyzed Electroreductive Cross-Electrophile Carbonylation to β/γ-Hydroxy Ketones.

The nickel catalyzed multi-component cross-electrophile carbonylation which emerges as a powerful and efficient method for constructing diverse ketones has attracted increasing attention of organic chemists. However, the selectivity of this reaction poses a significant challenge. In this work, we have developed a current-regulated selective nickel-catalyzed electroreductive cross-electrophile carbonylation, which offers a direct convergent synthesis of β/γ-hydroxy ketones, which represent pivotal structural motifs found in numerous natural products, bioactive molecules, pharmaceutical compounds, and essential building blocks.

An organic-inorganic hybrid ferroelastic with a near-room-temperature phase transition.

Organic-inorganic hybrid metal halides (OIMHs) with ferroelastic phase transition properties have recently attracted great attention due to their widespread application prospects in the fields of energy storage, sensors, switches, . However, most of the hybrid ferroelastics exhibit phase transition points () far beyond room temperature, which may limit their applications in mechanical switches and energy storage for daily working requirements. Herein, we synthesized a new zinc halide OIMH ferroelastic (,)-[BPHD]ZnBr (BPHD = 1,6-bis(piperidine-1-yl) hexa-2,4-diene diamide), which experiences a 2/1̄ type paraelastic-ferroelastic phase transition at a near-room-temperature of 285 K.

Stimuli-Responsive DNA Nanomachines for Intracellular Targeted Electrochemiluminescence Imaging in Single Cells.

Electrochemiluminescence (ECL) microscopy has emerged as a powerful technique for single-cell imaging owing to its unparalleled background-free imaging advantages. However, controlled intracellular ECL imaging remains challenging. Here, we developed a stimuli-responsive self-assembled DNA nanomachine that enables the ECL imaging of intracellular target biomolecules in single cells.

Flexible Fiber Sensors for Real-Time Monitoring of Redox Signaling Molecules in Exercise-Mimicking Engineered Skeletal Muscle.

Real-time monitoring of reactive oxygen and nitrogen species (RONS) in skeletal muscle provides crucial insights into the cause-and-effect relationships between physical activity and health benefits. However, the dynamic production of exercise-induced RONS remains poorly explored, due to the lack of sensing tools that can conform to soft skeletal muscle while monitor RONS release during exercise. Here we introduce dual flexible sensors via twisting carbon nanotubes into helical bundles of fibers and subsequent assembling electrochemical sensing components.

Towards the use of low-concentration CO2 sources by direct selective electrocatalytic reduction.

The direct CO2 reduction reaction (CO2RR) from simulated flue gas of various CO2 concentrations could minimize extra energy for pre-concentration processes to highly concentrated CO2 as a feed-stock. We investigate the challenges for CO2RR caused by low CO2 concentrations and provide strategies concerning the impact of the chosen electrocatalyst material and the selection of the electrolyte to attain high CO selectivity. We continuously feed CO2 mixed with N2 (the typical dilutant in flue gas) in various ratios to gas diffusion electrodes in a model flow-through electrolyzer.

Interleukin-37 promotes wound healing in diabetic mice by inhibiting the MAPK/NLRP3 pathway.

Aims/introduction: Diabetic foot ulcer (DFU) is a prevalent complication of diabetes characterized by heightened inflammation and impaired wound-healing processes. Interleukin-37 (IL-37) is a natural suppressor of innate inflammation. Here, we aim to investigate the potential of IL-37 in enhancing the healing process of diabetic wounds.

Polyketide production in a mangrove-associated fungus , induced by chemical epigenetic modification.

Studies on the chemical composition of endophytic fungus , isolated from the L., by using epigenetic modification to activate clusters of biosynthetic genes that are silenced or poorly expressed in fungi, resulting in obtainment of ten polyketides. Among these compounds were six new compounds, including cytosporin E2 (), cytosporin D1 (), cytosporin G1 (), cytosporin J1 (), cytosporin K1 (), cytosporin F1 (), and four known compounds, cytosporin E (), cytosporin Y3 (), cytosporin D (), and cytosporin L ().

Uranyl Speciation in Carbonate-Rich Hydrothermal Solutions: A Molecular Dynamics Study.

In this study, we employed classical molecular dynamics (CMD) and first-principles molecular dynamics (FPMD) simulations to investigate the speciation of uranyl in carbonate-rich hydrothermal solutions. The association constants (log) of uranyl carbonate complexes were derived from the potential of mean forces (PMFs) obtained from CMD simulations, and the acid constants (ps) of uranyl aqua ions were calculated using the FPMD-based vertical energy gap method. The results showed that uranyl ions could form stable mono- and bi-carbonate complexes at elevated temperatures and that uranyl aqua ions strongly hydrolyzed in neutral solutions at temperatures exceeding 473 K.

Effect of nebivolol on erectile function: a systematic review and meta-analysis of randomized controlled trials.

Background: Historically, β-blockers have been associated with erectile dysfunction (ED). Nebivolol, a third-generation β-blocker, may have had no negative effect on erectile function because of its vasodilating properties. However, the evidence level was considered either as low or very low.

Tumour necrosis factor-like weak inducer of apoptosis participates in the development of cutaneous fibrosis in an experimental systemic sclerosis model.

Objectives: Systemic sclerosis (SSc), a chronic autoimmune disorder, characterised by local inflammation and progressive fibrosis. Tumour necrosis factor-like weak inducer of apoptosis (TWEAK) has been established as a key mediator in fibrotic processes across multiple organs, primarily through binding to its receptor, fibroblast growth factor-inducible 14 (Fn14). However, the precise role of the TWEAK/Fn14 signalling in SSc pathogenesis remains unclear.

Reductive coupling of azonaphthalenes for the synthesis of BINAMs a diboron-enabled [5,5]-sigmatropic rearrangement.

The [5,5]-sigmatropic rearrangement is a less-studied reaction and may be strategically utilized to devise unique synthetic processes. Herein, we document a diboron-enabled [5,5]-sigmatropic rearrangement for practical synthesis of BINAM derivatives. Mechanistically, a concerted activation of azonaphthalenes by diboron creates a unique ten-membered transition state, which subsequently triggers a [5,5]-sigmatropic rearrangement.

Establishment of a survival rabbit model for laryngotracheal stenosis: A prospective randomized study.

Objective: To develop a reproducible survival rabbit model for laryngotracheal stenosis (LTS).

Methods: Seventy New Zealand white (NZW) rabbits were randomly divided into experimental groups ( = 30) and a control group ( = 40). In experimental groups, a nylon brush was inserted retrograde from the tracheotomy through the subglottis and rotated until a full layer circumferential mucosal injury to cartilage exposure, assisted by fiberoptic laryngoscopy (FOL) visualization.

The Combination of Super-Active Platelet Lysate and Acellular Amniotic Membrane Enhances Endometrial Receptivity, While Simultaneously Facilitating Endometrial Repair in Rats.

Purpose: To investigate the combined effects of super-active platelet lysate (sPL) and acellular amniotic membrane (AAM) in promoting endometrial repair and enhancing endometrial receptivity in rats.

Methods: The characteristics of sPL-AAM were examined through scanning electron microscopy, contact angle tester, and release experiments. We aimed to establish a rat model for endometrial injury.

Experimental Study and Hydration Mechanism Analysis of Geopolymer Multielement Net Slurry Self-Leveling Slurry Material.

In this project, cement-based composites reinforced with slag powder (abbreviated as SP), steel slag powder (abbreviated as SSP), and desulfurization gypsum (abbreviated as FGD) were used as the research objects, and the preparation, mechanical properties, and strengthening mechanism of the composites were systematically studied. A laser particle analyzer (Malvern Instruments Analysis) was used to determine that the particle sizes of the raw SSP, SP, and FGD materials were concentrated between 5 and 40 μm, indicating that they were fine-grained minerals. SSP and SP are highly active alkaline substances.