[Skin-sparing surgical revision in a woman with necrotizing fasciitis in her face].

Necrotizing fasciitis (NF) is a life-threatening infection which is treated with aggressive debridement, antibiotics, intensive care and hyperbaric oxygen. We present a case where a 66-year-old woman with NF of the face and neck following an eye infection was treated with skin-sparing surgical revision. The affected subcutaneous tissue as well as necrosis around the left eye was removed, but the skin was left untouched.

Folate deficiency-induced hyperhomocysteinemia attenuates, and folic acid supplementation restores, the functional activities of rat coagulation factors XII, X, and II.

Hyperhomocysteinemia (HH) constitutes a risk marker for thrombosis, but the pathophysiological mechanisms in thrombus formation are still unresolved. We investigated the influence of HH on single coagulation factor functions and evaluated the platelet GpIIb/IIIa receptor function in HH-induced changes in whole-blood coagulation profiles (WBCP). Three groups of 12 rats were investigated: control rats, folate deficient-HH (FD-HH) rats, and treated rats.

Hyperhomocysteinemia due to folate deficiency is thrombogenic in rats.

Although hyperhomocysteinemia (HH) appears to be an independent risk factor for thrombosis, the pathophysiologic mechanisms seen in thrombus formation are largely unresolved. The aim of the present study was to investigate whether HH is accompanied by thrombogenic alterations as assessed by whole blood thromboelastographic profiles. Severe (111 micro mol/L) and intermediate (42 micro mol/L) HH were induced in two series of rats by feeding them a folate-depleted diet.