Publications by authors named "Lisel M Koepl"
Information sources about prostate cancer treatment and outcomes are typically designed for patients. Little is known about the availability and utility of information for partners. The objectives of our study were to evaluate information sources used by partners to understand prostate cancer management options, their perceived usefulness, and the relationship between sources used and satisfaction with treatment experience.
View Article and Find Full Text PDFThe use of non-steroidal anti-inflammatory drugs (NSAIDs) is associated with reduced risk of colorectal neoplasia. Previous studies have reported that polymorphisms in NSAID-metabolizing enzymes central to NSAID metabolism including UDP-glucuronosyltransferases (UGT) and cytochrome P450 (CYP) 2C9 may modify this protective effect. We investigated whether 35 functionally relevant polymorphisms within CYP2C9 and UGT genes were associated with colorectal cancer risk or modified the protective effect of NSAIDs on colorectal cancer susceptibility, using 1,584 colorectal cancer cases and 2,516 unaffected sibling controls from the Colon Cancer Family Registry.
View Article and Find Full Text PDFIntroduction: In this prospective study of localized prostate cancer patients and their partners, we analyzed how partner issues evolve over time, focusing on satisfaction with care, influence of cancer treatment, and its impact on relationship with patient, cancer worry, and personal activities.
Aims: Our study aims were twofold: (i) to determine whether the impact of treatment on patients and partners moderate over time and (ii) if receiving surgery (i.e.
Article Synopsis
- The study investigates how referrals to various cancer specialists influence the treatment of non-small-cell lung cancer (NSCLC) in Medicare patients, focusing on factors related to both patients and primary care physicians.
- Using data from nearly 29,000 NSCLC patients, the research found that younger age, being white, higher income, and a non-family practice physician were associated with better referrals to medical oncologists.
- The findings indicate that seeing multiple types of cancer specialists significantly increased the likelihood of receiving guideline-based therapies, especially for stage III patients, but highlighted ongoing racial and income disparities in these referrals.
DNA methylation is an epigenetic modification essential for the regulation of gene expression that has been implicated in many diseases, including cancer. Few studies have investigated the wide range of potential predictors of global DNA methylation, including biomarkers. Here, we investigated associations between DNA methylation and dietary factors, sex-steroid hormones, metabolic, lipid, inflammation, immune and one-carbon biomarkers.
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