Publications by Lise Rudbaek Christensen

Publications by authors named "Lise Rudbaek Christensen"

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The anti-epileptic drug lamotrigine inhibits the CYP17A1 lyase reaction in vitro.

Cecilie Hurup Munkboel Lise Rudbæk Christensen Julie Islin Silvia Bonomo Lars Olsen

Biol Reprod

October 2018

The potential endocrine disrupting effects of the commonly prescribed anti-epileptic drug lamotrigine (LAM) were investigated using the H295R steroidogenic in vitro assay and computational chemistry methods. The H295R cells were exposed to different concentrations of LAM, and a multi-steroid LC-MS/MS method was applied to quantify the amount of secreted steroid hormones. LAM affected several steroid hormones in the steroidogenesis at therapeutic concentrations.

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