Impact of air pollution and noise exposure on cardiovascular disease incidence and mortality: A systematic review.

Background: The relationship between environmental pollutants, specifically air pollution and noise, and cardiovascular disease is well-recognized. However, their combined effects on cardiovascular health are not fully explored.

Objectives: To review evidence on the correlation between air pollution and noise exposure and cardiovascular disease incidence and mortality.

Sources of PM exposure misclassification in three Finnish register-based study populations and the impact on attenuation of health effect estimates.

Air pollution is a leading environmental health risk factor. The risk estimates, primarily based on air pollution epidemiology, are sensitive to exposure misclassification, which can result in underestimation. To address some of these challenges, our aim is to investigate how the length of the period over which the exposure is averaged, trends in long-term PM concentrations, and the seasonal variability are associated with each other.

Statistical Analysis Plan for the AIRCARD Study: Individual Long-Term Air and Noise Pollution Exposure and Cardiovascular Disease Incidence and Mortality - A Prospective Cohort Study Utilizing DANCAVAS and VIVA Screening Trials.

Introduction: The AIRCARD study is designed to investigate the relationship between long-term exposure to air and noise pollution and cardiovascular disease incidence and mortality. We aim to conduct a robust prospective cohort analysis assessing the cumulative and differential impacts of air and noise pollution exposure on cardiovascular disease and mortality. This study will adjust for relevant confounders, including traditional cardiovascular risk factors, socioeconomic indicators, and lipid-lowering agents.

Pregnancy outcomes as related to in utero exposure to air pollution and greenness: The Life-GAP Project.

Background: Lower birth weight and preterm birth may increase the risk of adverse health outcomes later in life. We examined whether maternal exposure to air pollution and greenness during pregnancy is associated with offspring birth weight and preterm birth.

Methods: We analyzed data on 4286 singleton births from 2358 mothers from Respiratory Health in Northern Europe, a prospective questionnaire-based cohort study (1990-2010).

Associations of long-term exposure to air pollution and greenness with incidence of chronic obstructive pulmonary disease in Northern Europe: The Life-GAP project.

Background: Prolonged exposure to air pollution has been linked to adverse respiratory health, yet the evidence concerning its association with chronic obstructive pulmonary disease (COPD) is inconsistent. The evidence of a greenness effect on chronic respiratory diseases is limited.

Objective: This study aimed to investigate the association between long-term exposure to particulate matter (PM and PM), black carbon (BC), nitrogen dioxide (NO), ozone (O) and greenness (as measured by the normalized difference vegetation index - NDVI) and incidence of self-reported chronic bronchitis or COPD (CB/COPD).

Monthly average air pollution models using geographically weighted regression in Europe from 2000 to 2019.

Detailed spatial models of monthly air pollution levels at a very fine spatial resolution (25 m) can help facilitate studies to explore critical time-windows of exposure at intermediate term. Seasonal changes in air pollution may affect both levels and spatial patterns of air pollution across Europe. We built Europe-wide land-use regression (LUR) models to estimate monthly concentrations of regulated air pollutants (NO, O, PM and PM) between 2000 and 2019.

Exposure to air pollution and risk of respiratory tract infections in the adult Danish population-a nationwide study.

Objectives: The association between air pollution and risk of respiratory tract infection (RTI) in adults needs to be clarified in settings with low to moderate levels of air pollution. We investigated this in the Danish population between 2004 and 2016.

Methods: We included 3 653 490 persons aged 18-64 years in a nested case-control study.

Long-term exposure to low-level air pollution and greenness and mortality in Northern Europe. The Life-GAP project.

Background: Air pollution has been linked to mortality, but there are few studies examining the association with different exposure time windows spanning across several decades. The evidence for the effects of green space and mortality is contradictory.

Objective: We investigated all-cause mortality in relation to exposure to particulate matter (PM and PM), black carbon (BC), nitrogen dioxide (NO), ozone (O) and greenness (normalized difference vegetation index - NDVI) across different exposure time windows.

Concomitant exposure to air pollution, green space and noise, and risk of myocardial infarction: a cohort study from Denmark.

Aims: The three correlated environmental exposures (air pollution, road traffic noise, and green space) have all been associated with the risk of myocardial infarction (MI). The present study aimed to analyse their independent and cumulative association with MI.

Methods And Results: In a cohort of all Danes aged 50 or older in the period 2005-17, 5-year time-weighted average exposure to fine particles (PM2.

Medium term moderate to low-level air pollution exposure is associated with higher C-reactive protein among healthy Danish blood donors.

Air pollution is a significant contributor to the global burden of disease with a plethora of associated health effects such as pulmonary and systemic inflammation. C-reactive protein (CRP) is associated with a wide range of diseases and is associated with several exposures. Studies on the effect of air pollution exposure on CRP levels in low to moderate pollution settings have shown inconsistent results.

Perspectives on environment and health research in Denmark.

Aims: We provide an overview of nationwide environmental data available for Denmark and its linkage potentials to individual-level records with the aim of promoting research on the potential impact of the local surrounding environment on human health.

Background: Researchers in Denmark have unique opportunities for conducting large population-based studies treating the entire Danish population as one big, open and dynamic cohort based on nationally complete population and health registries. So far, most research in this area has utilised individual- and family-level information to study the clustering of disease in families, comorbidities, risk of, and prognosis after, disease onset, and social gradients in disease risk.

Concomitant exposure to air pollution, green space, and noise and risk of stroke: a cohort study from Denmark.

Background: Air pollution, road traffic noise, and green space are correlated factors, associated with risk of stroke. We investigated their independent relationship with stroke in multi-exposure analyses and estimated their cumulative stroke burden.

Methods: For all persons, ≥50 years of age and living in Denmark from 2005 to 2017, we established complete address histories and estimated running 5-year mean exposure to fine particles (PM), ultrafine particles, elemental carbon, nitrogen dioxide (NO), and road traffic noise at the most, and least exposed façade.

Source-Specific Air Pollution Including Ultrafine Particles and Risk of Myocardial Infarction: A Nationwide Cohort Study from Denmark.

Background: Air pollution is negatively associated with cardiovascular health. Impediments to efficient regulation include lack of knowledge about which sources of air pollution contributes most to health burden and few studies on effects of the potentially more potent ultrafine particles (UFP).

Objective: The authors aimed to investigate myocardial infarction (MI) morbidity and specific types and sources of air pollution.

Early-Life Exposure to Ambient Air Pollution from Multiple Sources and Asthma Incidence in Children: A Nationwide Birth Cohort Study from Denmark.

Background: Ambient air pollution exposure has been associated with childhood asthma, but previous studies have primarily focused on prevalence of asthma and asthma-related outcomes and urban traffic-related exposures.

Objective: We examined nationwide associations between pre- and postnatal exposure to ambient air pollution components and asthma incidence in children age 0-19 y.

Methods: Asthma incidence was identified from hospital admission, emergency room, and outpatient contacts among all live-born singletons born in Denmark between 1998 and 2016.

Air pollution and stroke; effect modification by sociodemographic and environmental factors. A cohort study from Denmark.

Objectives: Air pollution increases the risk of stroke, but the literature on identifying susceptible subgroups of populations is scarce and inconsistent. The aim of this study was to investigate if the association between air pollution and risk of stroke differed by sociodemographic factors, financial stress, comorbid conditions, and residential road traffic noise, population density and green space.

Methods: We assessed long-term exposure to air pollution with ultrafine particles, PM, elemental carbon and NO for a cohort of 1,971,246 Danes aged 50-85 years.

Air pollution and myocardial infarction; effect modification by sociodemographic and environmental factors. A cohort study from Denmark.

Air pollution is associated with increased risk of myocardial infarction (MI), but it is unresolved to what extent the association is modified by factors such as socioeconomic status, comorbidities, financial stress, residential green space, or road traffic noise. We formed a cohort of all (n = 1,964,702) Danes, aged 50-85 years, with 65,311 cases of MI during the followed-up period 2005-2017. For all participants we established residential five-year running average exposure to particulate matter <2.

Long-term exposure to low-level particulate air pollution and Parkinson's disease diagnosis - A Finnish register-based study.

Background: There is mixed evidence for an association between particulate matter air pollution and Parkinson's disease despite biological plausibility.

Objectives: We studied the association between particulate air pollution, its components and Parkinson's disease (PD) risk.

Methods: We conducted a nested case-control study within the population of Finland using national registers.

'Source-specific' air pollution and risk of stroke in Denmark.

Background: Long-term air pollution is a risk factor for stroke. Which types and sources of air pollution contribute most to stroke in populations is unknown. We investigated whether risk of stroke differed by type and source of air pollution.

Effects of Sociodemographic Characteristics, Comorbidity, and Coexposures on the Association between Air Pollution and Type 2 Diabetes: A Nationwide Cohort Study.

Background: Exposure to air pollution has been associated with a higher risk of type 2 diabetes (T2D), but studies investigating whether deprived groups are more susceptible to the harmful effects of air pollution are inconsistent.

Objectives: We aimed to investigate whether the association between air pollution and T2D differed according to sociodemographic characteristics, comorbidity, and coexposures.

Methods: We estimated residential exposure to , ultrafine particles (UFP), elemental carbon, and for all persons living in Denmark in the period 2005-2017.

Exposure to ambient air pollution and lipid levels and blood pressure in an adult, Danish cohort.

Background: Air pollution is a well-recognized risk factor for cardiovascular disease. However, the mechanistic pathways underlying the association are not completely understood. Hence, further studies are required to shed light on potential mechanisms, through which air pollution may affect the development from subclinical to clinical cardiovascular disease.

PM air pollution components and mortality in Denmark.

Background: Ambient fine particulate matter (PM) causes millions of deaths every year worldwide. Identification of the most harmful types of PM would facilitate efficient prevention strategies.

Objectives: The aim of this study was to investigate associations between components of PM and mortality in a nation-wide Danish population.

Long-term exposure to transportation noise and risk of type 2 diabetes: A cohort study.

Background: Some studies have found transportation noise to be associated with higher diabetes risk. This includes studies based on millions of participants, relying entirely on register-based confounder adjustment, which raises concern about residual lifestyle confounding. We aimed to investigate associations between noise and type 2 diabetes (T2D), including investigation of effects of increasing confounder adjustment for register-data and lifestyle.

Present-day and future PM and O-related global and regional premature mortality in the EVAv6.0 health impact assessment model.

We used the EVAv6.0 system to estimate the present (2015) and future (2015-2050) global PM and O-related premature mortalities, using simulated surface concentrations from the GISS-E2.1-G Earth system model.