Publications by authors named "Lisbeth Eischer"

Article Synopsis
  • The study evaluates the Vienna Prediction Model (VPM) to identify patients with unprovoked venous thromboembolism (VTE) who are at low risk of recurrence after stopping anticoagulation treatment.
  • Among 818 patients, 520 had a predicted recurrence risk of ≤5.5%, with actual recurrence rates being 5.2% after 1 year and 11.2% after 2 years.
  • The VPM was found to underestimate recurrence risk in some cases, but recalibration improved its accuracy in identifying low-risk patients, with men showing higher recurrence rates than women.
View Article and Find Full Text PDF

The risk of recurrence after discontinuation of anticoagulation for a combined oral contraceptive (COC)-associated venous thromboembolism (VTE) is unclear. Therefore, we conducted a systematic review and meta-analysis to estimate the incidence of recurrent VTE among women with COC-associated VTE, unprovoked VTE and to compare the incidence of recurrent VTE between the two groups. The Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Embase Classic +Embase and Medline ALL to July 2020 and citations from included studies were searched.

View Article and Find Full Text PDF

Direct oral anticoagulants (DOACs) are safe and effective in cancer patients treated for venous thromboembolism (VTE) or atrial fibrillation (AF). Gastrectomy is the treatment of choice in patients with localized upper gastrointestinal cancer. DOACs are absorbed in the upper gastrointestinal tract, but to what extent is unclear.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to assess the risk of major bleeding in patients undergoing long-term anticoagulant therapy (up to 5 years) for a first unprovoked venous thromboembolism (VTE).
  • Analysis included 14 randomized controlled trials and 13 cohort studies, revealing a higher incidence of major bleeding events in patients taking vitamin K antagonists (VKAs) compared to direct oral anticoagulants (DOACs).
  • Significant risk factors for bleeding included being over 65 years old, having poor kidney function, a history of bleeding, and low hemoglobin levels.
View Article and Find Full Text PDF

Background: The long-term risk for recurrent venous thromboembolism (VTE) during extended anticoagulation for a first unprovoked VTE is uncertain.

Objectives: To determine the incidence of recurrent VTE during extended anticoagulation of up to 5 years in patients with a first unprovoked VTE.

Methods: MEDLINE, EMBASE, and the Cochrane CENTRAL were searched to identify randomized trials and prospective cohort studies reporting recurrent VTE among patients with a first unprovoked VTE who were to receive anticoagulation for a minimum of six additional months after completing ≥3 months of initial treatment.

View Article and Find Full Text PDF

Introduction: D-dimer measured shortly after discontinuation of anticoagulation by an immunoturbidimetric assay predicts the risk of recurrent venous thromboembolism (VTE). We assessed the performance of this assay over time and its association with recurrent VTE.

Materials And Methods: We followed 556 patients with a first VTE for a median of 9.

View Article and Find Full Text PDF

Patients with unprovoked deep-vein thrombosis (DVT) of the leg or pulmonary embolism (PE) have a high recurrence risk. How often these recurrences are provoked by a temporary risk condition is unknown. In a cohort of patients with unprovoked venous thromboembolism (VTE), we evaluated the clinical circumstances of recurrence.

View Article and Find Full Text PDF

Essentials Factor XI is a potential target for anticoagulation. The association between factor XI and venous thrombosis recurrence was tested in a cohort study. Low factor XI was associated with reduced risk of recurrent venous thrombosis.

View Article and Find Full Text PDF

Background: Patients with spinal cord injury (SCI) are at risk of thrombosis and bleeding. Data on the risks during rehabilitation are inconsistent, and thromboprophylactic strategies are heterogeneous. We aimed to evaluate the thrombotic risk and bleeding events of SCI patients during rehabilitation.

View Article and Find Full Text PDF

Venous thromboembolism (VTE) is a chronic disease, which tends to recur. Whether an abnormal fibrinolytic system is associated with an increased risk of VTE is unclear. We assessed the relationship between fibrinolytic capacity (reflected by clot lysis time [CLT]) and risk of recurrent VTE.

View Article and Find Full Text PDF

Background: Venous thromboembolism (VTE) is a multicausal disease which recurs. Hematocrit is associated with a thrombotic risk. We aimed to investigate if hematocrit is associated with the recurrence risk.

View Article and Find Full Text PDF

Risk of first venous thromboembolism (VTE) increases with age. We investigated whether age is related to the risk of recurrent VTE. We followed 694 patients for a mean of 40 months after first unprovoked proximal deep vein thrombosis (DVT) and/or pulmonary embolism (PE) and withdrawal of anticoagulants.

View Article and Find Full Text PDF