Publications by authors named "Lisanne C C J Smans"
Is Diagnosis and Subclassification of Adrenal Insufficiency as Easy as It Looks?
Front Horm Res
September 2017
The diagnosis of adrenal insufficiency (AI) is a challenge. Most signs and symptoms are nonspecific and vary considerably depending upon the underlying cause and degree of AI. Identification of AI is crucial because the disease may be life-threatening if left unrecognized.
View Article and Find Full Text PDFBackground: Health-related quality of life in patients with Addison's disease has been assessed in various European countries, indicating a reduced quality of life. However, no studies have addressed the impact of Addison's disease on physical activity.
Objective: The aim of this study was to investigate the quality of life in Dutch patients with Addison's disease particularly regarding the presence of fatigue and the ability to be physically active.
Article Synopsis
- - Adrenal crisis is a critical medical emergency that can be fatal if not diagnosed and treated promptly; despite being manageable for decades, many patients still face serious risks due to inadequate prevention or late intervention.
- - Gastrointestinal illnesses are a major trigger for adrenal crises, yet both patients and doctors often hesitate to increase glucocorticoid doses or switch to injections when necessary, worsening patient outcomes.
- - There is a lack of research on adrenal crises, highlighting the need for a review of existing literature to improve understanding of its incidence, symptoms, treatment methods, prevention techniques, and current steroid dosing guidelines in stressful scenarios.
Incidence of adrenal crisis in patients with adrenal insufficiency.
Clin Endocrinol (Oxf)
January 2016
Background: An adrenal crisis (AC) is a potential life-threatening event in patients with adrenal insufficiency (AI). This study aims to determine the incidence, causes, and risk factors of AC in AI.
Methods: Patients with AI diagnosed and treated at the University Medical Center Utrecht for the past 30 years were identified, and all medical records were assessed by two independent investigators.
Background: Previous studies have suggested that infections are an important cause of death in patients with Addison's disease, but epidemiological studies on the frequency of infections in this population are lacking.
Objective: To assess and compare the incidence risk of infections in patients with primary adrenal insufficiency with controls.
Design And Setting: We conducted a cohort study, using data from the Dutch PHARMO record linkage system, that links patients' demographics and medication histories to hospital admissions.
The famous and beautifully illustrated monograph "On the Constitutional and Local Effects of Disease of the Suprarenal Capsules" was published by Thomas Addison in 1855. This was the first description of the disease that now bears his name. Thomas Addison provided the first real contribution to the knowledge of adrenal function after three centuries of non-productive speculation and is one of the founders of modern endocrinology.
View Article and Find Full Text PDFDoes recovery of adrenal function occur in patients with autoimmune Addison's disease?
Clin Endocrinol (Oxf)
April 2011
Objective: We earlier discovered partial recovery in a patient with autoimmune Addison's disease. The aim of this study was to assess the occurrence of adrenocortical recovery in patients with autoimmune adrenalitis.
Design: Cross-sectional study.