Publications by authors named "Lisanne Baak"
Background: Perinatal arterial ischemic stroke (PAIS) is associated with adverse neurological outcomes. Quantification of ischemic lesions and consequent brain development in newborn infants relies on labor-intensive manual assessment of brain tissues and ischemic lesions. Hence, we propose an automatic method utilizing convolutional neural networks (CNNs) to segment brain tissues and ischemic lesions in MRI scans of infants suffering from PAIS.
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- Perinatal arterial ischemic stroke (PAIS) can lead to long-term neurodevelopmental issues, and this study reviews early predictors of outcomes in infants under four months of age.
- A systematic analysis of 41 studies involving 1395 infants found that MRI assessment of corticospinal tracts and standardized motor assessments are the best predictors of developing cerebral palsy, while techniques like (a)EEG and NIRS may help in predicting cognitive outcomes.
- The study highlights the need for further research to identify effective predictors for non-motor outcomes, such as behavior and language, after PAIS.
Background: Perinatal arterial ischaemic stroke (PAIS) is an important cause of neurodevelopmental disabilities. In this first-in-human study, we aimed to assess the feasibility and safety of intranasally delivered bone marrow-derived allogeneic mesenchymal stromal cells (MSCs) to treat PAIS in neonates.
Methods: In this open-label intervention study in collaboration with all neonatal intensive care units in the Netherlands, we included neonates born at full term (≥36 weeks of gestation) with MRI-confirmed PAIS in the middle cerebral artery region.