Application scenarios for a mobile hearing aid demonstrator with headphone form factor.

Objective: To describe application scenarios of a mobile device that provides a practical means for showcasing potential hearing aid benefits.

Design: A prototype of a hearing aid demonstrator based on circumaural headphones and a mobile signal processing platform was developed, providing core functions of a hearing aid, including several gain presets, in a hygienic, robust, and easy-to-use form factor. Speech intelligibility outcomes with the demonstrator and broadband level adaptations as potential fitting references were compared to outcomes with the own hearing aids of hearing-impaired participants.

The acetyltransferase p300 is recruited in trans to multiple enhancer sites by lncSmad7.

The histone acetyltransferase p300 (also known as KAT3B) is a general transcriptional coactivator that introduces the H3K27ac mark on enhancers triggering their activation and gene transcription. Genome-wide screenings demonstrated that a large fraction of long non-coding RNAs (lncRNAs) plays a role in cellular processes and organ development although the underlying molecular mechanisms remain largely unclear (1,2). We found 122 lncRNAs that interacts directly with p300.

HaTSPiL: A modular pipeline for high-throughput sequencing data analysis.

Background: Next generation sequencing methods are widely adopted for a large amount of scientific purposes, from pure research to health-related studies. The decreasing costs per analysis led to big amounts of generated data and to the subsequent improvement of software for the respective analyses. As a consequence, many approaches have been developed to chain different software in order to obtain reliable and reproducible workflows.

In vivo analysis of influenza A mRNA secondary structures identifies critical regulatory motifs.

The influenza A virus (IAV) is a continuous health threat to humans as well as animals due to its recurring epidemics and pandemics. The IAV genome is segmented and the eight negative-sense viral RNAs (vRNAs) are transcribed into positive sense complementary RNAs (cRNAs) and viral messenger RNAs (mRNAs) inside infected host cells. A role for the secondary structure of IAV mRNAs has been hypothesized and debated for many years, but knowledge on the structure mRNAs adopt in vivo is currently missing.

RNA Framework: an all-in-one toolkit for the analysis of RNA structures and post-transcriptional modifications.

RNA is emerging as a key regulator of a plethora of biological processes. While its study has remained elusive for decades, the recent advent of high-throughput sequencing technologies provided the unique opportunity to develop novel techniques for the study of RNA structure and post-transcriptional modifications. Nonetheless, most of the required downstream bioinformatics analyses steps are not easily reproducible, thus making the application of these techniques a prerogative of few laboratories.