Publications by authors named "Lisa-Marie Mar"
Article Synopsis
- High-grade endometrial stromal sarcomas (HGESSs) are aggressive uterine tumors that frequently have a specific genetic fusion (YWHAE::NUTM2) and recurrent alterations in the CDKN2A gene.
- In a study of 36 HGESS samples, researchers found that 18% had complete deletions and 14% had partial deletions of CDKN2A, which affected the presence of the p16 protein, a marker related to tumor behavior.
- The study indicated that the absence of p16 protein was linked to significantly worse survival outcomes in patients, suggesting that CDKN2A changes could drive tumor development and that p16 could be a useful prognostic marker in these cases
