Publications by authors named "Lisa-Marie Geertje Pohle"
Article Synopsis
- The spinal cord plays a crucial role in brain-body communication, but traditional noninvasive recording methods in humans face significant challenges.
- Researchers developed a new electrophysiological approach that uses high-density multichannel spinal recordings and advanced spatial-filtering analyses, allowing for detailed timing and sensitivity in spinal cord response assessments.
- This method was further expanded to include simultaneous recordings from peripheral, spinal, and cortical areas, providing evidence that integrative processing starts in the spinal cord, and was applied to study nociceptive responses during pain stimulation, paving the way for better understanding of brain-body interactions in health and disease.
Background And Purpose: The interaction of arrestins with G-protein coupled receptors (GPCRs) desensitizes agonist-dependent receptor responses and often leads to receptor internalization. GPCRs that internalize without arrestin have been classified as "class A" GPCRs whereas "class B" GPCRs co-internalize with arrestin into endosomes. The interaction of arrestins with GPCRs requires both agonist activation and receptor phosphorylation.
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