Publications by authors named "Lisa-Maria Schmitt"
Article Synopsis
- Primary pigmented nodular adrenocortical disease (PPNAD) is a rare cause of ACTH-independent Cushing syndrome (CS) that complicates diagnosis due to its similarities with other conditions.* -
- A 22-year-old female exhibited classic symptoms like weight gain and moon facies, but imaging tests showed normal adrenal glands, making it difficult to find the source of cortisol overproduction.* -
- Ultimately, adrenal vein sampling confirmed cortisol came from the adrenal glands, leading to successful treatment through bilateral adrenalectomy and a diagnosis of PPNAD linked to a genetic mutation associated with the Carney complex.*
The ATR-CHK1 pathway plays a fundamental role in the DNA damage response and is therefore an attractive target in cancer therapy. The antitumorous effect of ATR inhibitors is at least partly caused by synthetic lethality between ATR and various DNA repair genes. In previous studies, we have identified members of the B-family DNA polymerases as potential lethal partner for ATR, i.
View Article and Find Full Text PDFThe phosphoinositide 3-kinase-related kinase ATR is a central regulator of the DNA damage response. Its chemical inhibition eliminates subsets of cancer cells in various tumor types. This effect is caused at least partly by the synthetically lethal relationship between ATR and certain DNA repair genes.
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