Publications by authors named "Lisa van der Schee"
Article Synopsis
- Detection of lymphovascular invasion (LVI) in T1 colorectal cancer (CRC) varies across Dutch laboratories and significantly influences treatment decisions, particularly surgical resection rates.
- Patients diagnosed in laboratories with high LVI detection rates had higher surgical resection rates and a greater proportion of lymph node metastasis-negative surgeries compared to those from lower detection rate labs.
- However, despite these differences in surgical approach, high LVI detection did not lead to significantly better cancer recurrence outcomes, indicating potential risks without improved benefits for patients.
Background: The incidence of T1 colorectal cancer (CRC) has increased with the implementation of CRC screening programs. It is unknown whether the outcomes and risk models for T1 CRC based on non-screen-detected patients can be extrapolated to screen-detected T1 CRC. This study aimed to compare the stage distribution and oncologic outcomes of T1 CRC patients within and outside the screening program.
View Article and Find Full Text PDFArticle Synopsis
- The study looked at how stage I colorectal cancers (CRCs) found during screenings are treated compared to those found without screening in the Netherlands.
- It found that CRCs detected through screening were often at an earlier stage (T1) and were treated less invasively than those found without screening.
- Researchers want to understand if the choice of treatment was influenced by unknown factors related to the cancer or how skilled the doctors are who are doing the procedures.
A free resection margin (FRM) > 1 mm after local excision of a T1 colorectal cancer (CRC) is known to be associated with a low risk of local intramural residual cancer (LIRC). The risk is unclear, however, for FRMs between 0.1 to 1 mm.
View Article and Find Full Text PDFIntroduction: Local full-thickness resections of the scar (FTRS) after local excision of a T1 colorectal cancer (CRC) with uncertain resection margins is proposed as an alternative strategy to completion surgery (CS), provided that no local intramural residual cancer (LIRC) is found. However, a comparison on long-term oncological outcome between both strategies is missing.
Methods: A large cohort of patients with consecutive T1 CRC between 2000 and 2017 was used.