Publications by authors named "Lisa Yue"
Article Synopsis
- Genetic testing for children with hereditary cardiomyopathy is essential for family management and understanding emotional impacts, leading to a study on parental involvement in the process.
- A survey of 162 parents and 48 adolescents revealed that parents often disclosed genetic results to affected children, while emotions varied significantly based on test outcomes, affecting family dynamics.
- The study suggests that healthcare providers should improve genetic service structures to enhance communication between parents and adolescents regarding test results.
The histone methyltransferase EZH2 is frequently mutated in germinal center-derived diffuse large B-cell lymphoma and follicular lymphoma. To further characterize these EZH2 mutations in lymphomagenesis, we generated a mouse line where EZH2(Y641F) is expressed from a lymphocyte-specific promoter. Spleen cells isolated from the transgenic mice displayed a global increase in trimethylated H3K27, but the mice did not show an increased tendency to develop lymphoma.
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