Soybean genomics research community strategic plan: A vision for 2024-2028.

This strategic plan summarizes the major accomplishments achieved in the last quinquennial by the soybean [Glycine max (L.) Merr.] genetics and genomics research community and outlines key priorities for the next 5 years (2024-2028).

Expanding opportunities for chronic disease prevention for Hispanics: the Better Together REACH program in Pennsylvania.

Background: Hispanics in Lebanon and Reading, Pennsylvania, experience high levels of socioeconomic and health disparities in risk factors for chronic disease. In 2018, our community-academic coalition "Better Together" received a Racial and Ethnic Approaches to Community Health (REACH) award to improve healthy lifestyles. This report describes our work-in-progress and lessons learned to date from our REACH-supported initiatives in Lebanon and Reading.

Impact of a Prescription Produce Program on Diabetes and Cardiovascular Risk Outcomes.

Objective: To evaluate the impact of a fruit and vegetable prescription program on diabetes and cardiovascular risk outcomes.

Design: Single-arm pre-post study.

Setting: Primary care clinic in a community-based hospital.

Na1.2 EFL domain allosterically enhances Ca binding to sites I and II of WT and pathogenic calmodulin mutants bound to the channel CTD.

Neuronal voltage-gated sodium channel Na1.2 C-terminal domain (CTD) binds calmodulin (CaM) constitutively at its IQ motif. A solution structure (6BUT) and other NMR evidence showed that the CaM N domain (CaM) is structurally independent of the C-domain (CaM) whether CaM is bound to the Na1.

SARS-CoV-2 innate effector associations and viral load in early nasopharyngeal infection.

COVID-19 causes severe disease with poor outcomes. We tested the hypothesis that early SARS-CoV-2 viral infection disrupts innate immune responses. These changes may be important for understanding subsequent clinical outcomes.

SARS-CoV-2 Innate Effector Associations and Viral Load in Early Nasopharyngeal Infection.

To examine innate immune responses in early SARS-CoV-2 infection that may change clinical outcomes, we compared nasopharyngeal swab data from 20 virus-positive and 20 virus-negative individuals. Multiple innate immune-related and transcripts increased with infection and were strongly associated with increasing viral load. We found widespread discrepancies between transcription and translation.

Juvenile Justice Risk Factors and Functional Family Therapy Fidelity on Felony Recidivism.

Families ( = 5,884) received Functional Family Therapy (FFT) provided as part of court-ordered probation services by 11 community sites throughout Florida. Sites provided home-based FFT to families with male (72%) or female (28%) delinquent youth. Juvenile justice courts referred clients to these services in an effort to redirect them away from incarceration.

Summary of comparison between FFT-CW and Usual Care sample from Administration for Children's Services.

This evaluation compared the efficiency and effectiveness of Functional Family Therapy-Child Welfare (FFT-CW, n=1625) to Usual Care (UC: n=2250) in reducing child maltreatment. FFT-CW is a continuum of care model based on the family's risk status. In a child welfare setting, families received either UC or FFT-CW in a quasi-experimental, stepped wedge design across all five boroughs of New York City.

THE SHIKIMATE PATHWAY.

The shikimate pathway links metabolism of carbohydrates to biosynthesis of aromatic compounds. In a sequence of seven metabolic steps, phosphoenolpyruvate and erythrose 4-phosphate are converted to chorismate, the precursor of the aromatic amino acids and many aromatic secondary metabolites. All pathway intermediates can also be considered branch point compounds that may serve as substrates for other metabolic pathways.

The role of biotin in regulating 3-methylcrotonyl-coenzyme a carboxylase expression in Arabidopsis.

As a catalytic cofactor, biotin has a critical role in the enzymological mechanism of a number of enzymes that are essential in both catabolic and anabolic metabolic processes. In this study we demonstrate that biotin has additional non-catalytic functions in regulating gene expression in plants, which are biotin autotrophic organisms. Biotin controls expression of the biotin-containing enzyme, methylcrotonyl-coenzyme A (CoA) carboxylase by modulating the transcriptional, translational and/or posttranslational regulation of the expression of this enzyme.

Translocation of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase precursor into isolated chloroplasts.

A cDNA encoding 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase (EC 4.1.2.