Publications by authors named "Lisa Vogg"
Article Synopsis
- The germinal center (GC) reaction plays a vital role in the immune response by facilitating somatic hypermutation and the selection of high-affinity B cells, making the understanding of B cell gene functions essential.
- Traditional methods for studying B cell genes, like generating knock-out mice, are complex and time-consuming, but CRISPR technology has offered a more straightforward alternative, though it still faces challenges related to cost and efficiency.
- The authors developed a new CRISPR-Cas9 method for studying B cell gene functions that is quick and cost-effective, using adoptively transferred edited B cells to investigate gene roles, exemplified by examining the pro-apoptotic gene Fas in the GC selection process.
The intestinal epithelium harbours a unique lymphocyte population, the intraepithelial lymphocytes (IELs). A large fraction of IELs is represented by γδ T cells. Their role in epithelial homeostasis and immune response is well documented, but a conclusive view of their developmental pathway is still missing.
View Article and Find Full Text PDFThe clonal selection theory describes key features of adaptive immune responses of B and T cells. For αβ T cells and B cells, antigen recognition and selection principles are known at a detailed molecular level. The precise role of the antigen receptor in γδ T cells remains less well understood.
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