Intrauterine LPS inhibited arcuate Kiss1 expression, LH pulses, and ovarian function in rats.

In Brief: Uterine inflammatory diseases are a major cause of infertility in humans and domestic animals. The current findings that intrauterine lipopolysaccharide is absorbed in systemic circulation and attenuates ovarian cyclic activities could provide a basis for developing novel treatments to improve fertility.

Abstract: Uterine inflammatory diseases are a major cause of infertility in humans and domestic animals.