Publications by authors named "Lisa Thibes"
Cancer stem cells (CSCs) are a highly tumorigenic subpopulation of the cancer cells within a tumor that drive tumor initiation, progression, and therapy resistance. In general, stem cell niche provides a specific microenvironment in which stem cells are present in an undifferentiated and self-renewable state. CSC niche is a specialized tumor microenvironment for CSCs which provides cues for their maintenance and propagation.
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- Due to poor performance of synthetic vascular prostheses in small-diameter revascularization, researchers are developing biological substitutes using the human amniotic membrane (HAM) as a cost-effective alternative.
- The study outlines a new method for producing vascular grafts by twisting HAM into threads, with results showing that the physical and mechanical properties of these threads can be easily adjusted.
- Testing revealed that gamma irradiation and decellularization did not affect the HAM's ability to support blood vessel formation, making it a promising option for creating allogeneic, small-diameter tissue-engineered vascular grafts without expensive production methods.
Influence of material properties and boundary conditions on patient-specific models.
Comput Methods Biomech Biomed Engin
March 2021
Patient-specific finite element models (PSFEM) are becoming more and more used. Different methods for assigning their material properties were studied on PSFEMs of 9 tibias along with the minimal required length of the CT acquisition window. Material properties are generally attributed to the PSFEM using relationships linking the grayscale of CT scans to the elasticity moduli.
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