Publications by authors named "Lisa Skelton"
Dendritic cells (DC) are essential to the initiation of an immune response due to their unique ability to take-up and process Ag, translocate to lymph nodes, and present processed Ag to naive T cells. Many chemokines, chemokine receptors and other G protein-coupled receptors (GPCRs) are implicated in these various aspects of DC biology. Through microarray analysis, we compared expression levels of chemokines, their cognate receptors, and selected GPCRs in human monocytes and in vitro monocyte-derived immature and mature DC.
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- ADAMs are transmembrane glycoproteins involved in various cellular processes such as cell adhesion, fusion, and signaling, with ADAM8 showing particular expression in immune and nervous systems.
- ADAM8 undergoes a processing mechanism in which its propeptide is removed, influenced by its zinc-binding motif, and can be further processed by its ectodomain in cell co-transfection experiments.
- The study found that ADAM8 can facilitate cell adhesion and has proteolytic activity, indicating its role as a sheddase and in the regulation of cell interactions.