Publications by authors named "Lisa S Eurelings"
Background: Previous findings suggest that apathy symptoms independently of depressive symptoms measured using the Geriatric Depression Scale (GDS) are associated with cardiovascular disease (CVD) in older individuals.
Aims: To study whether apathy and depressive symptoms in older people are associated with future CVD, stroke, and mortality using individual patient-data meta-analysis.
Methods: Medline, Embase, and PsycInfo databases up to September 3, 2013, were systematically searched without language restrictions.
Article Synopsis
- Scientists wanted to see if treating heart health could help prevent dementia in older people.
- They did a study with people aged 70-78 in the Netherlands, with some getting special care for 6 years and others getting regular care.
- After following them for about 6.7 years, they found no big difference in dementia rates or disability scores between the two groups, meaning the special care didn’t help as expected.
Background: In old age, both apathy and depression have been associated with an increased cardiovascular disease (CVD) risk. This study evaluated the mediating role of cardiovascular risk factors in the relationship of apathy and mood symptoms with incident CVD.
Methods: Prospective cohort study of 1,790 community-dwelling older individuals (70-78 years) without a history of CVD or stroke.
Background: Systemic low-grade inflammation has repeatedly been associated with depression in old age, but the relationship with apathy is less clear. The present study assessed whether C-reactive protein (CRP) is differentially associated with symptoms of apathy and depression.
Methods: A population-based cohort study was carried-out.
Objective: Although depression is considered to be associated with cardiovascular disease (CVD), specifically symptoms of apathy have been strongly associated with a history of CVD in recent studies. In this study, we prospectively assess whether symptoms of apathy and depression are independent risk factors for incident CVD and stroke.
Methods: We carried out a prospective cohort study of 1810 community-dwelling older individuals (70-78 years) without a history of CVD or stroke.
Context: Apathy in community-dwelling elderly individuals has been associated with a history of stroke and other cardiovascular disease.
Objective: To assess the relationship between symptoms of apathy and cardiovascular risk factors or disease (stroke or other) in a large sample of elderly people aged 70 to 78 years without depression or dementia.
Design: Cross-sectional data analysis within an ongoing cluster-randomized, open, multicenter trial.
Characteristics of dyshoric capillary cerebral amyloid angiopathy.
J Neuropathol Exp Neurol
November 2010
Cerebral amyloid angiopathy (CAA) affects brain parenchymal and leptomeningeal arteries and arterioles but sometimes involves capillaries (capCAA) with spread of the amyloid into the surrounding neuropil, that is, dyshoric changes. We determined the relationship between capCAA and larger vessel CAA, β amyloid (Aβ) plaques, neurofibrillary changes, inflammation, and apolipoprotein E (APOE) in 22 cases of dyshoric capCAA using immunohistochemistry. The dyshoric changes contained predominantly Aβ1-40, whereas dense bulblike deposits adjacent to the capillary wall contained mostly Aβ1-42.
View Article and Find Full Text PDFContext: Delirium is a common and serious complication in elderly patients. Evidence suggests that delirium is associated with long-term poor outcome but delirium often occurs in individuals with more severe underlying disease.
Objective: To assess the association between delirium in elderly patients and long-term poor outcome, defined as mortality, institutionalization, or dementia, while controlling for important confounders.