Publications by authors named "Lisa Raque"
Article Synopsis
- Toxoplasma gondii is a widespread parasite that can severely affect fetal brain development, leading to major disorders.
- In an experiment, pregnant guinea pigs were infected with T. gondii, revealing that the parasite targets and infects various brain cells, including neural progenitor cells, neurons, and astrocytes.
- The study found a significant reduction in both neuron and neural progenitor cell counts, highlighting impaired neurogenesis as a key issue in infected fetuses, and also identified microgliosis linked to the presence of T. gondii in the brain.
Background: Toxoplasma gondii is an obligate intracellular parasite with a worldwide distribution. Congenital infection in humans and animals may lead to severe symptoms in the offspring, especially in the brain. A suitable animal model for human congenital toxoplasmosis is currently lacking.
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