Evaluation of nanoparticle delivered cisplatin in beagles.

Intracranial neoplasia is a significant cause of morbidity and mortality in both human and veterinary patients, and is difficult to treat with traditional therapeutic methods. Cisplatin is a platinum (Pt)-containing chemotherapeutic agent approved by the Food and Drug Administration; however, substantial limitations exist for its application in canine brain tumor treatment due to the difficulty in crossing the blood-brain barrier (BBB), development of resistance, and toxicity. A modified Pt(iv)-prodrug of cisplatin, Platin-M, was recently shown to be deliverable to the brain via a biocompatible mitochondria-targeted lipophilic polymeric nanoparticle (NP) that carries the drug across the BBB and to the mitochondria.

Correlation of near-infrared spectroscopy and direct pressure monitoring in an acute porcine compartmental syndrome model.

Objective: To correlate near-infrared spectroscopy (NIRS) and the tibial intracompartmental perfusion pressure (TIPP) in an acute limb compartmental syndrome.

Methods: Landrace swine were subdivided into 2 groups: plasma infusion (n = 16) and blunt trauma plus plasma infusion (n = 15). NIRS sensors were placed over the craniolateral muscle compartment of proximal both tibiae.

Evaluation of a rapid pressor response test in healthy cats.

Objective: To evaluate angiotensin I and angiotensin II rapid pressor response tests in healthy cats.

Animals: 6 purpose-bred sexually intact male cats.

Procedures: Telemetric blood pressure (BP) implants were placed in all cats.

In vitro effects of meloxicam on metabolism in articular chondrocytes from dogs with naturally occurring osteoarthritis.

Objective: To assess effects of in vitro meloxicam exposure on metabolism in articular chondrocytes from dogs with naturally occurring osteoarthritis.

Sample: Femoral head cartilage from 16 dogs undergoing total hip replacement.

Procedures: Articular cartilage samples were obtained.