Publications by authors named "Lisa Pointner"
The SLIPPS Learning Event Recording Tool for students in Advanced Practice Nursing: A translation and content validation study.
Z Evid Fortbild Qual Gesundhwes
December 2024
Article Synopsis
- * The validation process included a systematic translation, cognitive validation with nurse input, and a pilot survey with nursing students, which showed the tool is user-friendly and effective in prompting reflection on various patient safety events.
- * This marks the first application of the German SLERT in nursing education, emphasizing the importance of standardized reporting and reflection to enhance patient safety practices.
Toll-like receptors of the human immune system are specialized pathogen detectors able to link innate and adaptive immune responses. TLR ligands include among others bacteria-, mycoplasma- or virus-derived compounds such as lipids, lipo- and glycoproteins and nucleic acids. Not only are genetic variations in TLR-related genes associated with the pathogenesis of allergic diseases, including asthma and allergic rhinitis, their expression also differs between allergic and non-allergic individuals.
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- - The increasing use of nanomaterials in consumer products, particularly cosmetics, raises safety concerns as nanoparticles can easily penetrate biological barriers and interact with allergens, potentially affecting immune responses.
- - This study focuses on how silica nanoparticles interact with the birch pollen allergen Bet v 1, examining key immunotoxicity events in human immune cells, such as allergen uptake and presentation.
- - Results show that when allergens interact with silica nanoparticles, it leads to enhanced immune responses that favor a type 1 inflammatory profile, suggesting that this interaction may reduce allergic sensitization rather than worsen it.
Article Synopsis
- Seasonal exposure to birch pollen (BP) triggers allergic reactions, with Toll-like receptor 4 (TLR4) playing a potential role in this process that hasn't been fully understood yet.
- The study investigates how TLR4 affects the activation of dendritic cells (DCs) by birch pollen extracts (BPE) and assesses the contributions of lipopolysaccharides (LPS) and other components in BPE.
- Results indicate that TLR4 is crucial for the activation of mouse and human DCs by BPE, and that this activation influences T cell responses, highlighting the significance of TLR4 in birch pollen-induced allergic inflammation.
B Cell Functions in the Development of Type I Allergy and Induction of Immune Tolerance.
Handb Exp Pharmacol
November 2021
B cells are key players in the mechanisms underlying allergic sensitization, allergic reactions, and tolerance to allergens. Allergen-specific immune responses are initiated when peptide:MHCII complexes on dendritic cells are recognized by antigen-specific receptors on T cells followed by interactions between costimulatory molecules on the surfaces of B and T cells. In the presence of IL-4, such T-B cell interactions result in clonal expansion and isotype class-switching to IgE in B cells, which will further differentiate into either memory B cells or PCs.
View Article and Find Full Text PDFThe mechanisms involved in the induction of allergic sensitization by pollen are not fully understood. Within the last few decades, findings from epidemiological and experimental studies support the notion that allergic sensitization is not only dependent on the genetics of the host and environmental factors, but also on intrinsic features of the allergenic source itself. In this review, we summarize the current concepts and newest advances in research focusing on the initial mechanisms inducing pollen sensitization.
View Article and Find Full Text PDFPara-Phenylenediamine (PPD) is an aromatic amine used in hair dyes and in temporary black henna tattoos, which is a frequent cause of allergic contact dermatitis (ACD). ACD is a skin inflammatory reaction characterized by modifications such as spongiosis, exocytosis and acanthosis. The aim of this study is to characterize the expression and the role of IL-20-related cytokines, including IL-19, IL-20, IL-22 and IL-24, in ACD.
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