Emerging role for the Serum Response Factor (SRF) as a potential therapeutic target in cancer.

Introduction: The Serum Response Factor (SRF) is a transcription factor involved in three hallmarks of cancer: the promotion of cell proliferation, cell death resistance and invasion and metastasis induction. Many studies have demonstrated a leading role in the development and progression of multiple cancer types, thus highlighting the potential of SRF as a prognostic biomarker and therapeutic target, especially for cancers with poor prognosis.

Areas Covered: This review examines the role of SRF in several cancers in promoting cellular processes associated with cancer development and progression.