Publications by authors named "Lisa Pankewitz"
Article Synopsis
- A new extension to the 'Cobiveco' biventricular coordinate system has been introduced to improve anatomical registration of heart ventricles by including complex regions like outflow tracts and valve annuli.
- The proposed CobivecoX system employs a unique algorithm to identify intervalvular bridges and assign specific coordinates for precise local positioning in these areas.
- Validation of this method was conducted using curated three-dimensional models from cardiac MRI, ensuring that universal cardiac coordinates can be effectively applied to diverse ventricular shapes relevant to both normal hearts and those with congenital conditions.
A single experimental method alone often fails to provide the resolution, accuracy, and coverage needed to model integral membrane proteins (IMPs). Integrating computation with experimental data is a powerful approach to supplement missing structural information with atomic detail. We combine RosettaNMR with experimentally-derived paramagnetic NMR restraints to guide membrane protein structure prediction.
View Article and Find Full Text PDFArticle Synopsis
- - G protein-coupled receptors (GPCRs) are the largest family of membrane proteins and are key targets for drug development, especially class A GPCRs, which affect many physiological processes in humans.
- - About 45% of GPCRs bind flexible peptides or segments from larger protein ligands, with existing research indicating these peptides can change shape significantly when bound to receptors.
- - To improve knowledge on how these peptides interact with receptors and inform peptidomimetic drug design, more research is needed on peptide ligands in their complexed state with the corresponding GPCRs.