Fibrocystin Is Essential to Cellular Control of Adhesion and Epithelial Morphogenesis.

Mutations of the gene cause autosomal recessive polycystic kidney disease (ARPKD). encodes fibrocystin/polyductin (FPC), a ciliary type I membrane protein of largely unknown function, suggested to affect adhesion signaling of cells. Contributions of epithelial cell adhesion and contractility to the disease process are elusive.