The Impact of Zinc on Manganese Bioavailability and Cytotoxicity in HepG2 Cells.

Scope: Despite their essentiality, several studies have shown that either manganese (Mn) or zinc (Zn) overexposure may lead to detrimental health effects. Although Mn is transported by some of the SLC family transporters that translocate Zn, the role of Zn in hepatocellular Mn transport and Mn-induced toxicity have yet to be fully characterized.

Methods And Results: The human hepatoma cell line, HepG2, is utilized.