Publications by authors named "Lisa Maria Metz"

Introduction: Platelet activation and thrombus formation is crucial for hemostasis, but also trigger arterial thrombosis. Calcium mobilization plays an important role in platelet activation, because many cellular processes depend on the level of intracellular Ca ([Ca](i)), such as integrin activation, degranulation, cytoskeletal reorganization. Different modulators of Ca signaling have been implied, such as STIM1, Orai1, CyPA, SGK1, etc.

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Article Synopsis
  • * Pannexin-1 (Panx1) channels play a critical role in inflammation and were found to influence AAA formation through effects on endothelial cells and platelets, particularly after platelet activation.
  • * Research showed that while Panx1 levels were higher in AAA patients and animal models, targeting Panx1 in platelets didn't significantly alter aortic remodeling or diameter changes, indicating that inflammation modulation alone isn't enough to impact AAA progression.
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Pannexin-1 (PANX1) is a transmembrane protein that forms ion channels as hexamers on the plasma membrane. Electrophysiological studies prove that PANX1 has a high conductance for adenosine triphosphate (ATP), which plays an important role as a signal molecule in platelet activation. Recently, it was shown that PANX1 channels modulate platelet functions.

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Cardiovascular diseases (CVDs) are the leading cause of death globally-partly a consequence of increased population size and ageing-and are major contributors to reduced quality of life. Platelets play a major role in hemostasis and thrombosis. While platelet activation and aggregation are essential for hemostasis at sites of vascular injury, uncontrolled platelet activation leads to pathological thrombus formation and provokes thrombosis leading to myocardial infarction or stroke.

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