Publications by authors named "Lisa M Manna"
Article Synopsis
- - AST-004 is a small molecule that targets adenosine receptors and shows promise for protecting the brain after strokes and injuries, aiming to assess its safety and how it's processed in the body during a phase I clinical trial on healthy individuals.
- - The study involved giving varying doses of AST-004 to different groups of participants and then analyzing its levels in blood, cerebrospinal fluid (CSF), and urine; no serious side effects were observed, though headaches were reported by some.
- - Findings indicated that AST-004 is safe at higher concentrations than previously effective in animal studies and that it reaches highest levels in CSF an hour after infusion, suggesting it may be suitable for further testing in treating strokes and brain injuries.
