Publications by authors named "Lisa M Herman"
Article Synopsis
- Interleukin-12 (IL-12) is made up of two protein chains, p40 and p35, and their coordinated expression is key for a proper immune response.
- Interferon-gamma (IFN-gamma) helps macrophages produce more IL-12, but when IRF-1 is absent, there's a significant drop in IL-12 p35 production while p40 remains unaffected.
- IRF-1 is crucial for the transcription of the IL-12 p35 gene, as it interacts with specific elements in the gene's promoter and works with other signals like LPS to enhance its activation.
